Chandraprabha Vati

Names and identification

Language	Name
English	Chandraprabha Vati

Where is it described in the classical texts?

Sharangdhara Samhita, Madhyama Khanda, Chapter 7 (Vatika Adhikara). Also described in Bhaishajya Ratnavali (Prameha Rogadhikara) and Chakradatta. One of the most referenced polyherbal formulations across multiple classical Ayurvedic texts.

How does it work?

• Multi-target metabolic modulation: Network pharmacology reveals 328 bioactives acting on multiple targets for obesity, hyperglycemia, and dyslipidemia simultaneously.
• Anti-inflammatory cytokine suppression: Reduces IL-6 and TNF-alpha secretion in urinary tract and bladder tissue.
• Anti-hyperglycemic action: Modulates glucose metabolism and insulin sensitivity pathways, attenuating lipid profile alterations.
• Mineral bioavailability enhancement: Shilajit-derived fulvic acid increases absorption of zinc and magnesium essential for enzymatic and reproductive functions.
• Diuretic and litholytic effects: Promotes urine flow and may help dissolve urinary calculi through combined action of Gokshura, Shilajit, and other ingredients.

Which traditional uses are supported by research?

• Urinary tract disorders and cystitis (validated by in vitro anti-inflammatory studies on bladder cells)
• Prameha/Diabetes management (validated by antidiabetic animal studies and clinical evaluation)
• Metabolic syndrome management (validated by 2024 network pharmacology analysis)
• Male reproductive health and oligospermia (validated by clinical study showing 15% improvement in sperm count and motility)

What do recent clinical trials show?

5 further claims previously listed here could not be traced to a published paper and have been removed. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.

Recent safety updates

• No major side effects or serious adverse reactions reported at recommended therapeutic doses (250-500 mg twice daily). Over-dosage may cause mild burning sensation in the abdomen.
• Contains Loha Bhasma (iron calx) and other mineral bhasmas; should be avoided in conditions of iron overload and not taken concurrently with certain modern medicines without medical supervision.
• Contraindicated in pregnancy. Extra precautions advised for children and elderly. Patients with renal impairment should consult a physician due to mineral content.

What is it made of?

Mineral/Elemental Profile

• Primary component: Mineral-derived preparation
• Note: Composition varies by specific preparation method

Analytical Methods: XRD, ICP-OES, SEM-EDS

Dosage forms and preparation

Dosage Forms: Vati (tablet/pill), Modern compressed tablet, Capsule (modern)

Standard Dosage: 250-500 mg twice daily with warm water or milk, as per AFI Part I

Bioavailability: Guggulu acts as yogavahi (bioenhancer), carrying active compounds to target tissues. Shilajatu (fulvic acid) enhances mineral absorption. Bhasma nano-particles (50-100 nm) provide high bioavailability. Piperine from Trikatu enhances absorption of all co-ingredients.

Optimal Timing: After meals, twice daily, or as directed. Often taken with meals for urogenital conditions.

Shelf Life: 5 years from date of manufacture as per ASU guidelines (Rasa/Bhasma-containing formulations)

Storage: Store in airtight containers in a cool, dry place. Protect from moisture. Temperature not exceeding 30°C.

Marker Compounds: Fulvic acid (from Shilajatu), Z-Guggulsterone, E-Guggulsterone, Piperine, Gallic acid, Embelin (from Vidanga)

Quality Parameters: Weight variation (±5%), hardness, friability (<1%), disintegration time (<30 min), moisture (<6%), Loha Bhasma quality tests, free mercury/arsenic (nil/within limits), total heavy metals within pharmacopoeial limits, Shilajatu identity (fulvic acid content), HPTLC fingerprint, microbial limits

Vehicle (Anupana): Warm water, milk, or as directed based on condition

Synergistic Combinations

• Gokshuradi Guggulu|Gokshuradi Guggulu
• Punarnavadi Kwath
• Shilapravang Vati
• Varunadi Kwath