Gokshuradi Guggulu
Gokshuradi Guggulu is a classical Ayurvedic guggulu, a resin-based preparation. Listed in Ayurvedic Formulary of India (AFI) Part I; monographed in Ayurvedic Pharmacopoeia of India (API); Gokshura (Tribulus terrestris) fruit individually listed in API Part I. The Ayurvedic Formulary of India (Part I, entry 5:3) lists 10 ingredients: Goksura 1.344 kg, Water for decoction 8.064 l reduced to 4.032 l, Pura (guggulu)-suddha 336 g, Sunthi 48 g, Marica 48 g, Pippali 48 g, Haritaki 48 g, Bibhitaka 48 g, Amalaki 48 g and Musta 48 g.
| Also known as | Gokshuradi Guggulu, GokshuradiGuggulu |
|---|---|
| Pharmacopoeia status | Listed in Ayurvedic Formulary of India (AFI) Part I; monographed in Ayurvedic Pharmacopoeia of India (API); Gokshura (Tribulus terrestris) fruit individually listed in API Part I |
Composition
As given in the Ayurvedic Formulary of India, Part I, entry 5:3 (GOKSURADI GUGGULU), which cites Sarngadharasamhita, Madhyamakhanda, Adhyaya 7; 84-86. Names, parts and quantities are transcribed as printed and checked row by row against the book. Manufacturers' versions of a classical formulation can differ from the formulary.
| # | Ingredient | Part | Quantity |
|---|---|---|---|
| 1 | Goksura * | fruit | 1.344 kg |
| 2 | Water for decoction * | 8.064 l reduced to 4.032 l | |
| 3 | Pura (guggulu)-suddha (guggulu) | exudate | 336 g |
| 4 | Sunthi * | rhizome | 48 g |
| 5 | Marica * | fruit | 48 g |
| 6 | Pippali | fruit | 48 g |
| 7 | Haritaki * | pericarp | 48 g |
| 8 | Bibhitaka * | pericarp | 48 g |
| 9 | Amalaki * | pericarp | 48 g |
| 10 | Musta * | rhizome | 48 g |
* The scanned text was damaged at this row and the name was read from the entry's own Sanskrit verse.
The Formulary gives the dose as 3 g, with anupana, the vehicle it is taken with, of musta kvatha; pasanabheda kvatha; usira. This is what the Formulary records for the classical preparation. It is not a dose for any product, and not advice to take anything.
The evidence at a glance
1paper on this site for this drug, every one with a DOI.
- 1Laboratory and animal studies
A count is not a conclusion and a tier is a study design, not a verdict. Everything listed here is laboratory or animal work, which does not show an effect in people.true See the research index for how papers are tiered.
Names and identification
| Language | Name |
|---|---|
| English | Gokshuradi Guggulu |
Where is it described in the classical texts?
Sharangdhara Samhita (Madhyama Khanda, Chapter 7); also referenced in Bhaishajya Ratnavali (Mutrakrichra/Ashmari Chikitsa)
How does it work?
- Glomerular filtration enhancement: Steroidal saponins (protodioscin, diosgenin) from Gokshura (Tribulus terrestris) increase renal blood flow and glomerular filtration rate, promoting diuresis
- Anti-lithiatic action: Gokshura constituents inhibit calcium oxalate crystal nucleation and aggregation
- Anti-inflammatory and joint protection: Guggulsterones modulate cytokine pathways (NF-kB inhibition) to reduce inflammation in joints and urinary tract
- Urinary tract tonification: The cold potency (Sheeta Virya) and anabolizing (Brimhana) effect of Gokshura nourishes and strengthens urinary tract tissues
Which traditional uses are supported by research?
These summaries come from the source notes, which do not name the studies behind them.
- Ashmari (urinary stones): traditionally used for urinary stones. A pilot study reported a decrease in stone recurrence.
- Traditionally used for urinary tract complaints such as dysuria, burning micturition and UTI.
- Traditionally used to support kidney function.
- Traditionally used to support the kidneys in diabetic nephropathy.
What do recent studies show?
No study for this section could be traced to a published paper. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.
Recent safety updates
- Generally well tolerated; may cause mild GI discomfort; patients with kidney disease should use under medical supervision; avoid in pregnancy and lactation
- Gokshura may interact with antihypertensive and antidiabetic medications due to its diuretic and hypoglycemic potential; guggulu component may interact with anticoagulants
What is it made of?
The Ayurvedic Formulary of India recipe, every ingredient with its part and quantity, is in the composition table near the top of this page.
Dosage forms and preparation
Dosage Forms: Guggulu (resinous pill/tablet), Modern compressed tablet, Capsule (modern)
Standard Dosage: 250-500 mg twice or thrice daily with warm water. The Ayurvedic Formulary of India, Part I, entry 5:3 states a dose of 3 g; that is a different unit from the figure above and the two cannot be compared without knowing the preparation’s density or tablet mass. The formulary’s anupana: musta kvatha; pasanabheda kvatha; usira. The formulary attributes this formula to Sarngadharasamhita, Madhyamakhanda, Adhyaya 7; 84-86.
Optimal Timing: After meals, twice or thrice daily, for Mutrakrichra (urinary disorders) and Ashmari (calculi)
Storage: Store in airtight containers in a cool, dry place. Temperature not exceeding 30°C. Guggulu preparations become harder with age, some texts say this improves potency.
Marker Compounds: Z-Guggulsterone, E-Guggulsterone, Protodioscin, Diosgenin (from Gokshura), Piperine, Gallic acid
Vehicle (Anupana): Warm water or Punarnavadi Kwath for urinary conditions
Synergistic Combinations
- Chandraprabha Vati
- Punarnavadi Kashayam
- Varunadi Kashayam
- Shilajatu
What manufacturers publish about this preparation
Disclosure first. This site is published by Age Ayurveda, which sells Ayurvedic products, though not this preparation. Every cell states what that company's own product page carried when it was read, not our judgement of it. There is no score, no rank and no winner here, and the table is in alphabetical order for that reason.
The formulary entry above fixes the ingredients and the quantity of each. Whether you can check a particular product against it depends on what its manufacturer publishes. Of the 5 companies surveyed that sell a product under this name, this is what their pages carried when they were read on 8 October 2026.
| Company | What its product page publishes |
|---|---|
| Maharishi Ayurveda | Neither an ingredient list nor quantities |
| Patanjali Ayurved | An ingredient list, without quantities |
| Sandu Pharmaceuticals | Neither an ingredient list nor quantities |
| Shree Dhootapapeshwar | Ingredients and the quantity of each |
| The Arya Vaidya Pharmacy, Coimbatore | Neither an ingredient list nor quantities |
This measures what each company publishes, not the quality of anything it makes. A company that publishes nothing here may make an excellent preparation, and the label in the box is a separate, regulated surface that is not what was read. What disclosure changes is whether a reader, a pharmacist or an answer engine can check a product against the formulary entry it claims.
Method, the full counts across every company surveyed, and what this measurement got wrong the first time: which manufacturers publish what is in the bottle. The URL of every page read is recorded in brand-disclosure.json. If a row here is wrong, including where the correction favours a company other than ours, tell us and we will fix it and say that we did. How the same companies' stated doses compare with the formulary dose, preparation by preparation: Ayurvedic company doses against the Ayurvedic Formulary of India.
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Laboratory and animal studies1
- 2022. Oral toxicity evaluation of gokshuradi guggulu, an ayurvedic formulationDrug and chemical toxicology. PMID 33685313 · doi:10.1080/01480545.2021.1894725
Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.
Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.
Educational reference only. Nothing on this page is medical advice, a diagnosis, or a recommendation to take anything. Traditional uses and research findings are reported as published, not as claims about what any product does. If you take prescribed medication, raise any interaction with the prescriber rather than acting on a page. See our editorial standards.