Krimighna Vati
Krimighna Vati is a classical Ayurvedic vati, a herbal tablet or pill. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.
| Also known as | Krimighna Vati, KrimighnaVati |
|---|---|
| Pharmacopoeia status | Listed in Ayurvedic Formulary of India (AFI); Krimighna Gana (antiparasitic group) recognized in all major Samhitas; Vidanga (Embelia ribes) individually monographed in Ayurvedic Pharmacopoeia of India (API) Part I; Azadirachta indica in API and Indian Pharmacopoeia |
Names and identification
| Language | Name |
|---|---|
| English | Krimighna Vati |
Key Ingredients
- Vidanga (Embelia ribes) fruit
- Neem (Azadirachta indica) leaf/bark
- Haridra (Curcuma longa - Turmeric) rhizome
- Pippali (Piper longum)
- Haritaki (Terminalia chebula)
- Vacha (Acorus calamus)
- Kampillaka (Mallotus philippensis)
Where is it described in the classical texts?
Charaka Samhita (Vimana Sthana, Chapter 7 - Krimighna Gana/Dashemani); also referenced in Sushruta Samhita, Ashtanga Hridayam (Krimighna Gana group of 10 antiparasitic herbs), and Bhaishajya Ratnavali
How does it work?
- Parasitic membrane disruption: Vidanga’s embelin alkaloids impair parasitic cell membranes by interfering with mitochondrial electron transport chain, causing parasite death
- Growth inhibition: Neem’s azadirachtin disrupts parasitic growth by interfering with ecdysone-mediated molting cycle, preventing larval development and reproduction
- Anti-inflammatory gut healing: Haridra (curcumin) provides anti-inflammatory and antimicrobial effects in damaged gut mucosa, promoting healing of parasite-induced tissue damage
- Digestive fire enhancement: Pippali and Vacha enhance Agni (digestive fire), creating an inhospitable environment for parasites and preventing reinfection by improving gut immunity
- Ama mobilization: Haritaki gently mobilizes Ama (toxic residue) from the gut while Pippali amplifies absorption through enhanced Srota (channel) penetration
Which traditional uses are supported by research?
- Anthelmintic activity validated through case study confirming efficacy against Hymenolepis nana tapeworm infection
- Broad-spectrum antiparasitic action validated through demonstrated membrane-disrupting and growth-inhibiting mechanisms of Vidanga and Neem
- Intestinal health restoration validated through anti-inflammatory and antimicrobial properties of curcumin (Haridra) in gut mucosa healing
- Skin parasite management (Kushtha/Krimi) validated through traditional use in parasitic skin conditions with confirmed antimicrobial activity of Neem and Haridra
What do recent clinical trials show?
3 further claims previously listed here could not be traced to a published paper and have been removed. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.
Recent safety updates
- Generally safe at recommended doses for short-term antiparasitic courses (7-14 days); may cause mild GI discomfort or loose stools during parasite expulsion phase; avoid in pregnancy and lactation
- Kampillaka is a potent purgative - dose must be carefully controlled; not recommended for children under 5 years without physician guidance; should be followed by probiotic restoration after treatment course; confirm parasitic infection through stool examination before use
What is it made of?
Mineral/Elemental Profile
- Primary component: Mineral-derived preparation
- Note: Composition varies by specific preparation method
Analytical Methods: XRD, ICP-OES, SEM-EDS
Dosage forms and preparation
Dosage Forms: Vati (tablet/pill), Modern compressed tablet, Capsule (modern)
Standard Dosage: 250-500 mg twice or thrice daily with warm water, as per AFI Part I
Bioavailability: Embelin (from Vidanga) is well-absorbed orally with anthelmintic activity at therapeutic doses. Rottlerin from Kampillaka acts as contact anthelmintic in the GI tract — does not need systemic absorption for action. Combined oral and luminal activity provides comprehensive anthelmintic effect.
Optimal Timing: On empty stomach, morning (Abhukta kala), for 3-7 days course. Follow with mild purgative (Eranda Taila or Triphala) to expel worms.
Shelf Life: 3 years from date of manufacture as per ASU guidelines for Vati
Storage: Store in airtight containers in a cool, dry place. Temperature not exceeding 30°C.
Marker Compounds: Embelin, Rottlerin (from Kampillaka), Butin (from Palasha), Butrin, Palasonin
Quality Parameters: Weight variation (±5%), hardness, friability (<1%), disintegration time (<30 min), moisture (<6%), embelin content by HPLC from Vidanga, rottlerin from Kampillaka, total tannins, HPTLC fingerprint, microbial limits, heavy metals
Vehicle (Anupana): Warm water or buttermilk. Some texts recommend with jaggery for pediatric use.
Synergistic Combinations
- Vidangarishta
- Krimikuthara Rasa
- Palasha Kwath
- Triphala Churna (as adjuvant laxative)
Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.
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