# Krimighna Vati > Krimighna Vati is a classical Ayurvedic vati, a herbal tablet or pill. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence. ## Key facts - **Pharmacopoeia status:** Listed in Ayurvedic Formulary of India (AFI); Krimighna Gana (antiparasitic group) recognized in all major Samhitas; Vidanga (Embelia ribes) individually monographed in Ayurvedic Pharmacopoeia of India (API) Part I; Azadirachta indica in API and Indian Pharmacopoeia ## Names and identification | Language | Name | |----------|------| | English | [Krimighna Vati](/formulation/krimighna-vati/) | ## Key Ingredients - [Vidanga](/herb/vidanga/) (Embelia ribes) fruit - [Neem](/herb/neem/) (Azadirachta indica) leaf/bark - [Haridra](/herb/haridra/) (Curcuma longa - [Turmeric](/herb/turmeric/)) rhizome - [Pippali](/herb/pippali/) (Piper longum) - [Haritaki](/herb/haritaki/) (Terminalia chebula) - [Vacha](/herb/vacha/) (Acorus calamus) - [Kampillaka](/herb/kampillaka/) (Mallotus philippensis) ## Where is it described in the classical texts? Charaka Samhita (Vimana Sthana, Chapter 7 - Krimighna Gana/Dashemani); also referenced in Sushruta Samhita, Ashtanga Hridayam (Krimighna Gana group of 10 antiparasitic herbs), and Bhaishajya Ratnavali ## How does it work? - Parasitic membrane disruption: [Vidanga](/herb/vidanga/)'s [embelin](/glossary/compounds-d-g/#embelin) [alkaloids](/glossary/compounds-1-a/#alkaloids) impair parasitic cell membranes by interfering with mitochondrial electron transport chain, causing parasite death - Growth inhibition: [Neem](/herb/neem/)'s [azadirachtin](/glossary/compounds-a-c/#azadirachtin) disrupts parasitic growth by interfering with ecdysone-mediated molting cycle, preventing larval development and reproduction - Anti-inflammatory gut healing: [Haridra](/herb/haridra/) ([curcumin](/herb/curcumin/)) provides anti-inflammatory and [antimicrobial](/reference/antimicrobial/) effects in damaged gut mucosa, promoting healing of parasite-induced tissue damage - Digestive fire enhancement: [Pippali](/herb/pippali/) and [Vacha](/herb/vacha/) enhance Agni (digestive fire), creating an inhospitable environment for parasites and preventing reinfection by improving gut immunity - Ama mobilization: [Haritaki](/herb/haritaki/) gently mobilizes Ama (toxic residue) from the gut while [Pippali](/herb/pippali/) amplifies absorption through enhanced Srota (channel) penetration ## Which traditional uses are supported by research? - Anthelmintic activity validated through case study confirming efficacy against Hymenolepis nana tapeworm infection - Broad-spectrum antiparasitic action validated through demonstrated membrane-disrupting and growth-inhibiting mechanisms of [Vidanga](/herb/vidanga/) and [Neem](/herb/neem/) - Intestinal health restoration validated through anti-inflammatory and antimicrobial properties of [curcumin](/herb/curcumin/) ([Haridra](/herb/haridra/)) in gut mucosa healing - Skin parasite management (Kushtha/Krimi) validated through traditional use in parasitic skin conditions with confirmed antimicrobial activity of [Neem](/herb/neem/) and [Haridra](/herb/haridra/) ## What do recent clinical trials show? *3 further claims previously listed here could not be traced to a published paper and have been removed. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.* ## Recent safety updates - Generally safe at recommended doses for short-term antiparasitic courses (7-14 days); may cause mild GI discomfort or loose stools during parasite expulsion phase; avoid in pregnancy and lactation - [Kampillaka](/herb/kampillaka/) is a potent purgative - dose must be carefully controlled; not recommended for children under 5 years without physician guidance; should be followed by probiotic restoration after treatment course; confirm parasitic infection through stool examination before use ## What is it made of? ### Mineral/Elemental Profile - **Primary component:** Mineral-derived preparation - **Note:** Composition varies by specific preparation method **Analytical Methods:** XRD, ICP-OES, SEM-EDS ## Dosage forms and preparation **Dosage Forms:** Vati (tablet/pill), Modern compressed tablet, Capsule (modern) **Standard Dosage:** 250-500 mg twice or thrice daily with warm water, as per AFI Part I **Bioavailability:** Embelin (from [Vidanga](/herb/vidanga/)) is well-absorbed orally with anthelmintic activity at therapeutic doses. Rottlerin from [Kampillaka](/herb/kampillaka/) acts as contact anthelmintic in the GI tract — does not need systemic absorption for action. Combined oral and luminal activity provides comprehensive anthelmintic effect. **Optimal Timing:** On empty stomach, morning (Abhukta kala), for 3-7 days course. Follow with mild purgative ([Eranda](/herb/eranda/) Taila or [Triphala](/herb/triphala/)) to expel worms. **Shelf Life:** 3 years from date of manufacture as per ASU guidelines for Vati **Storage:** Store in airtight containers in a cool, dry place. Temperature not exceeding 30°C. **Marker Compounds:** Embelin, Rottlerin (from [Kampillaka](/herb/kampillaka/)), Butin (from [Palasha](/herb/palasha/)), [Butrin](/glossary/compounds-a-c/#butrin), Palasonin **Quality Parameters:** Weight variation (±5%), hardness, friability (<1%), disintegration time (<30 min), moisture (<6%), embelin content by HPLC from [Vidanga](/herb/vidanga/), rottlerin from Kampillaka, total [tannins](/reference/tannins/), HPTLC fingerprint, microbial limits, heavy metals **Vehicle (Anupana):** Warm water or buttermilk. Some texts recommend with jaggery for pediatric use. ### Synergistic Combinations - [Vidangarishta](/formulation/vidangarishta/) - Krimikuthara Rasa - [Palasha](/herb/palasha/) Kwath - [Triphala](/herb/triphala/) Churna (as adjuvant [laxative](/reference/laxative/)) --- Canonical version of this page: https://nighantu.ageayurveda.com/formulation/krimighna-vati/ ## Sources - Amidha Ayurveda Herb Database (700+ herbs, CC-BY-4.0) - Web research (clinical trials, WHO monographs, safety databases) - Ayurvedic Pharmacopoeia of India - Classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Bhavaprakasha Nighantu) Published by Age Ayurveda in the Nighantu. Educational reference only, not medical advice. Incorporates material from the Amidha Ayurveda Herb Database under CC BY 4.0.