Mamsarohini
Mamsarohini is a substance used in the Ayurvedic materia medica. Significant intestinal and hepatic first-pass metabolism. P-glycoprotein efflux limits absorption. Co-administration with piperine inhibits P-gp and CYP3A4, increasing berberine bioavailability by 2-fold.
Names and identification
| Language | Name |
|---|---|
| English | Mamsarohini |
Ayurvedic pharmacology (Dravyaguna)
| Property | Value | Description |
|---|---|---|
| Rasa (Taste) | Kashaya | Primary taste |
| Guna (Quality) | Laghu, Ruksha | Physical quality |
| Virya (Potency) | Sheeta | Heating/Cooling effect |
| Vipaka (Post-digestive) | Katu | Post-digestive effect |
What is it made of?
Mineral/Elemental Profile
- Primary component: Mineral-derived preparation
- Note: Composition varies by specific preparation method
Analytical Methods: XRD, ICP-OES, SEM-EDS
Dosage forms and preparation
Dosage Forms: Churna (powder), Kwatha (decoction), Capsules, Tablets, Avaleha (confection), Ghrita (medicated ghee)
Standard Dosage: 1-3 g rhizome powder per day; 30-50 mL decoction twice daily; 250-500 mg standardized extract twice daily
Bioavailability: Berberine and related protoberberine alkaloids have inherently low oral bioavailability (approximately 5% for berberine). Significant intestinal and hepatic first-pass metabolism. P-glycoprotein efflux limits absorption. Co-administration with piperine inhibits P-gp and CYP3A4, increasing berberine bioavailability by 2-fold. Ghrita-based preparations may improve lipophilic alkaloid absorption.
Optimal Timing: Before meals for digestive and hepatic stimulant effects; empty stomach for maximum berberine absorption; evening dose for wound healing and tissue repair
Standardized Extract: Bark extract (10:1 hydroalcoholic) standardized to minimum 3% total alkaloids (as berberine equivalents). Aqueous extract for Kwatha with minimum 1.5% alkaloid content. Lipid-based nano-formulation for enhanced berberine delivery.
Shelf Life: 30 months for bark powder; 36 months for tablets/capsules; 18 months for decoctions; 24 months for Ghrita
Storage: Store below 25 deg C in airtight, light-resistant containers. Berberine is photosensitive - amber packaging mandatory. Protect from moisture. Ghrita in clean glass containers at room temperature.
Marker Compounds: Berberine, Palmatine, Jatrorrhizine, Columbamine, Magnoflorine, Beta-sitosterol, Lupeol
Extraction Methods
- Hydroalcoholic extraction (70% ethanol)
- Acid-water extraction for alkaloid enrichment
- Aqueous decoction
- Supercritical CO2 extraction
- Cold maceration in dilute HCl for berberine isolation
Synergistic Combinations
- Kutki (hepatoprotective and bitter tonic synergy)
- Haridra (anti-inflammatory and antimicrobial)
- Daruharidra (berberine-type alkaloid potentiation)
- Chirata (bitter tonic and febrifuge combination)
- Pippali (bioenhancer for berberine absorption)
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