# Mamsarohini

> Mamsarohini is a substance used in the Ayurvedic materia medica. Significant intestinal and hepatic first-pass metabolism. P-glycoprotein efflux limits absorption. Co-administration with piperine inhibits P-gp and CYP3A4, increasing berberine bioavailability by 2-fold.

## Names and identification

| Language | Name |
|----------|------|
| English | Mamsarohini |

## Ayurvedic pharmacology (Dravyaguna)

| Property | Value | Description |
|----------|-------|-------------|
| **Rasa** (Taste) | Kashaya | Primary taste |
| **Guna** (Quality) | Laghu, Ruksha | Physical quality |
| **Virya** (Potency) | Sheeta | Heating/Cooling effect |
| **Vipaka** (Post-digestive) | Katu | Post-digestive effect |

## What is it made of?

### Mineral/Elemental Profile

- **Primary component:** Mineral-derived preparation
- **Note:** Composition varies by specific preparation method

**Analytical Methods:** XRD, ICP-OES, SEM-EDS

## Dosage forms and preparation

**Dosage Forms:** Churna (powder), Kwatha (decoction), Capsules, Tablets, Avaleha (confection), [Ghrita](/herb/ghrita/) (medicated ghee)

**Standard Dosage:** 1-3 g rhizome powder per day; 30-50 mL decoction twice daily; 250-500 mg standardized extract twice daily

**Bioavailability:** [Berberine](/glossary/compounds-a-c/#berberine) and related protoberberine [alkaloids](/glossary/compounds-1-a/#alkaloids) have inherently low oral bioavailability (approximately 5% for [berberine](/glossary/compounds-a-c/#berberine)). Significant intestinal and hepatic first-pass metabolism. P-glycoprotein efflux limits absorption. Co-administration with [piperine](/reference/piperine/) inhibits P-gp and CYP3A4, increasing berberine bioavailability by 2-fold. [Ghrita](/herb/ghrita/)-based preparations may improve lipophilic alkaloid absorption.

**Optimal Timing:** Before meals for digestive and hepatic stimulant effects; empty stomach for maximum berberine absorption; evening dose for wound healing and tissue repair

**Standardized Extract:** Bark extract (10:1 hydroalcoholic) standardized to minimum 3% total alkaloids (as berberine equivalents). Aqueous extract for Kwatha with minimum 1.5% alkaloid content. Lipid-based nano-formulation for enhanced berberine delivery.

**Shelf Life:** 30 months for bark powder; 36 months for tablets/capsules; 18 months for decoctions; 24 months for Ghrita

**Storage:** Store below 25 deg C in airtight, light-resistant containers. Berberine is photosensitive - amber packaging mandatory. Protect from moisture. Ghrita in clean glass containers at room temperature.

**Marker Compounds:** Berberine, [Palmatine](/glossary/compounds-o-q/#palmatine), [Jatrorrhizine](/glossary/compounds-g-l/#jatrorrhizine), [Columbamine](/glossary/compounds-c-d/#columbamine), [Magnoflorine](/glossary/compounds-l-o/#magnoflorine), Beta-[sitosterol](/glossary/compounds-q-t/#sitosterol), [Lupeol](/reference/lupeol/)

### Extraction Methods

- Hydroalcoholic extraction (70% ethanol)
- Acid-water extraction for alkaloid enrichment
- Aqueous decoction
- Supercritical CO2 extraction
- Cold maceration in dilute HCl for berberine isolation

### Synergistic Combinations

- Kutki ([hepatoprotective](/reference/hepatoprotective/) and bitter tonic synergy)
- [Haridra](/herb/haridra/) (anti-inflammatory and [antimicrobial](/reference/antimicrobial/))
- [Daruharidra](/herb/daruharidra/) (berberine-type alkaloid potentiation)
- Chirata (bitter tonic and febrifuge combination)
- [Pippali](/herb/pippali/) (bioenhancer for berberine absorption)

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Canonical version of this page: https://nighantu.ageayurveda.com/herb/mamsarohini/

## Sources

- Amidha Ayurveda Herb Database (700+ herbs, CC-BY-4.0)
- Ayurvedic Pharmacopoeia of India

Published by Age Ayurveda in the Nighantu. Educational reference only, not medical advice.
Incorporates material from the Amidha Ayurveda Herb Database under CC BY 4.0.