Yashada Bhasma
Yashada Bhasma is a bhasma, a mineral or metal preparation reduced to ash by repeated calcination.
| Substance type | Mineral or metal preparation, not a plant |
|---|---|
| Also known as | Yashada Bhasma, YashadaBhasma |
The evidence at a glance
4papers on this site for this drug, published 2015 to 2025, every one with a DOI.
- 1Other clinical studies and reviews
- 3Laboratory and animal studies
A count is not a conclusion and a tier is a study design, not a verdict. Everything listed here is laboratory or animal work, which does not show an effect in people. Each paper is listed with what it measured on the page below. See the research index for how papers are tiered.
Names and identification
| Language | Name |
|---|---|
| English | Yashada Bhasma |
Key Phytochemical Constituents
- Zinc oxide (ZnO) nanoparticles (200-500 nm) with hexagonal wurtzite structure
- Trace iron, manganese, copper from processing
- Organic compounds from herbal trituration media
- Silicon and aluminum as trace impurities from crucible materials
How does it work?
- Animal studies report improved glucose tolerance, lower blood glucose levels, and modulation of insulin secretion, proposed to act via zinc-mediated enhancement of insulin receptor sensitivity
- Antioxidant activity through zinc-dependent superoxide dismutase (SOD) activation and ROS scavenging, protecting cells from oxidative stress damage
- Antimicrobial effect via ZnO nanoparticle-mediated disruption of bacterial cell membranes and generation of reactive oxygen species toxic to microorganisms
- Wound healing promotion through zinc-dependent collagen synthesis, cell proliferation stimulation, and immune cell recruitment to injury sites
- Anti-angiogenic activity through modulation of vascular endothelial growth factor (VEGF) pathways
Which traditional uses are supported by research?
These summaries come from the source notes, which do not name the studies behind them.
- Diabetes (Prameha/Madhumeha): traditionally used for Prameha and Madhumeha. Several studies have reported improvements in glucose parameters. It has also drawn interest in modern nanomedicine research.
- Eye diseases (Netra Roga): traditionally used for Netra Roga. Modern ophthalmology research has described a role for zinc in retinal health and in macular degeneration.
- Skin disorders and wound healing: traditionally used for skin disorders and wounds. Dermatological research has described a role for zinc in wound healing, collagen synthesis and skin integrity.
What do recent studies show?
- Nille GC, Bhuyan M, Gupta LN and others 2025. Characterization and potential novel applications of zinc-based traditional medicine, Yashad Bhasma. Journal of Ayurveda and integrative medicine. PMID 40886520 · doi:10.1016/j.jaim.2025.101188
Comprehensive characterization of Yashada Bhasma revealing antimicrobial, antioxidant, and anti-angiogenic activities. Novel applications identified beyond traditional uses. - Umrani RD, Paknikar KM 2015. Jasada bhasma, a Zinc-Based Ayurvedic Preparation: Contemporary Evidence of Antidiabetic Activity Inspires Development of a Nanomedicine. Evidence-based complementary and alternative medicine : eCAM. PMID 25866533 · doi:10.1155/2015/193156
Four weeks treatment with zinc ash (1-10 mg/kg) improved glucose tolerance (16-19%), lowered blood glucose (20-33%), and reduced serum insulin levels (27-32%). Inspired development of modern zinc nanomedicine. - Balkrishna A, Sharma D, Sharma RK and others 2023. Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn(2+) Bioavailability. ACS omega. PMID 36713743 · doi:10.1021/acsomega.2c05391
Classical calcination process produces nano ZnO particles with enhanced Zn2+ bioavailability compared to commercial zinc supplements. The Ayurvedic process creates unique surface chemistry favoring absorption. - Chavare A, Chowdari P, Ghosh S and others 2017. Safety and bioactivity studies of Jasad Bhasma and its in-process intermediate in Swiss mice. Journal of ethnopharmacology. PMID 27377339 · doi:10.1016/j.jep.2016.06.048
No major cytotoxicity at tested dose levels. No behavioral abnormality, clinical signs, or mortality. SGOT, SGPT, and serum urea not significantly altered, indicating no major organ toxicity. No major toxicity was observed in mice at the doses tested.
Recent safety updates
- No major organ toxicity at tested doses in a mouse study. Liver and kidney function markers (SGOT, SGPT, serum urea) remained within normal limits in animal studies.
- WELL-TOLERATED: No behavioral abnormalities, clinical signs, or mortality observed at tested dose levels in Swiss mice
- ZINC TOXICITY THRESHOLD: Zinc has established upper intake limits (40 mg/day for adults per NIH). Excessive zinc can cause copper deficiency, nausea, and immune dysfunction.
- ENHANCED BIOAVAILABILITY: Classical preparation method creates ZnO nanoparticles with enhanced bioavailability
What is it made of?
Mineral/Elemental Profile
- Zinc oxide (ZnO): Major component
- Zinc (Zn): >85%
- Iron (Fe): Trace
- Copper (Cu): Trace
Dosage forms and preparation
Dosage Forms: Bhasma
Standard Dosage: 125–250 mg
Optimal Timing: With honey; after meals to reduce GI irritation
Storage: Airtight, dry container
Marker Compounds: Zinc oxide (ZnO), Trace minerals
Vehicle (Anupana): Honey, Guduchi Swarasa, or Nimba Swarasa for Prameha
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Other clinical studies and reviews1
- 2015. Jasada bhasma, a Zinc-Based Ayurvedic Preparation: Contemporary Evidence of Antidiabetic Activity Inspires Development of a NanomedicineEvidence-based complementary and alternative medicine : eCAM. PMID 25866533 · doi:10.1155/2015/193156
Laboratory and animal studies3
- 2025. Characterization and potential novel applications of zinc-based traditional medicine, Yashad BhasmaJournal of Ayurveda and integrative medicine. PMID 40886520 · doi:10.1016/j.jaim.2025.101188
- 2023. Investigating the Role of Classical Ayurveda-Based Incineration Process on the Synthesis of Zinc Oxide Based Jasada Bhasma Nanoparticles and Zn(2+) BioavailabilityACS omega. PMID 36713743 · doi:10.1021/acsomega.2c05391
- 2017. Safety and bioactivity studies of Jasad Bhasma and its in-process intermediate in Swiss miceJournal of ethnopharmacology. PMID 27377339 · doi:10.1016/j.jep.2016.06.048
Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.
Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.
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