Putikaranja
Putikaranja is a substance used in the Ayurvedic materia medica. Millettia pinnata) seeds have moderate oral bioavailability (25-40%). Furanoflavonoids are lipophilic (log P >3) and benefit from lipid co-administration. Seed oil serves as a natural self-emulsifying delivery vehicle for lipophilic actives.
Names and identification
| Language | Name |
|---|---|
| English | Putikaranja |
Ayurvedic pharmacology (Dravyaguna)
| Property | Value | Description |
|---|---|---|
| Rasa (Taste) | Tikta, Katu | Primary taste |
| Guna (Quality) | Laghu, Tikshna | Physical quality |
| Virya (Potency) | Ushna | Heating/Cooling effect |
| Vipaka (Post-digestive) | Katu | Post-digestive effect |
What is it made of?
Mineral/Elemental Profile
- Primary component: Mineral-derived preparation
- Note: Composition varies by specific preparation method
Analytical Methods: XRD, ICP-OES, SEM-EDS
Dosage forms and preparation
Dosage Forms: Churna (seed powder), Kwatha (bark decoction), Capsule, Tablet, Taila (seed oil, external), Lepa (paste), Ointment
Standard Dosage: 1-3 g seed powder daily; 3-5 g bark powder daily; 15-20 mL decoction twice daily; topical oil/paste as directed
Bioavailability: Karanjin and pongamol from Pongamia pinnata (syn. Millettia pinnata) seeds have moderate oral bioavailability (25-40%). Furanoflavonoids are lipophilic (log P >3) and benefit from lipid co-administration. Seed oil serves as a natural self-emulsifying delivery vehicle for lipophilic actives. Pongapin shows rapid absorption (Tmax 1-2 h). Topical bioavailability of seed oil actives is good for dermatological applications.
Optimal Timing: Oral (seed/bark): after meals. Topical oil: apply at night, avoid sun exposure on treated areas for 12 hours. For skin conditions: apply thin layer twice daily.
Standardized Extract: Putikaranja seed extract (8:1) standardized to karanjin >5%, pongamol >2%. Seed oil with karanjin >2%, acid value <10 mg KOH/g. Bark extract with total flavonoids >3%.
Shelf Life: Seed oil: 12-18 months; Seed powder: 12-18 months; Extract: 24 months; Capsules: 24 months; Bark powder: 18-24 months
Storage: Seed oil: amber glass or HDPE, below 25 deg C, protect from light and oxidation. Powder: airtight, below 25 deg C, RH <50%. Seeds: cool, dry, pest-proof storage.
Marker Compounds: Karanjin, Pongamol, Pongapin, Kanjone, Furanoflavonoids, Beta-sitosterol, Glabrin, Pinnatin
Extraction Methods
- Cold-press seed oil extraction
- Hydroalcoholic extraction (60-70% ethanol) of seeds/bark
- Methanol extraction for furanoflavonoid profiling
- Aqueous decoction of bark
- Soxhlet extraction with hexane for oil followed by ethanol for defatted residue
- Supercritical CO2 for karanjin-enriched fraction
Synergistic Combinations
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