Mukta Pishti
Mukta Pishti is a pishti, a pearl-derived calcium preparation made by fine trituration without heating, unlike the heat-processed Mukta Bhasma.
| Substance type | Mineral or metal preparation, not a plant |
|---|---|
| Also known as | Mukta Pishti, MuktaPishti |
The evidence at a glance
1paper on this site for this drug, every one with a DOI.
- 1Laboratory and animal studies
A count is not a conclusion and a tier is a study design, not a verdict. Everything listed here is laboratory or animal work, which does not show an effect in people.true See the research index for how papers are tiered.
Names and identification
| Language | Name |
|---|---|
| English | Mukta Pishti |
How does it work?
- Acid-neutralizing and gastroprotective: Calcium carbonate (aragonite form) directly neutralizes gastric acid; the ultra-fine particle size from traditional trituration enhances surface area and buffering capacity
- Anxiolytic and cardiac calming: Conchiolin peptides may cross the blood-brain barrier and modulate GABAergic and serotonergic neurotransmission
- Pitta-pacifying cooling action: The high calcium content combined with organic pearl matrix provides systemic cooling effect
- Bone mineralization support: Bioavailable calcium from aragonite form is absorbed and contributes to bone mineral density
Which traditional uses are supported by research?
These summaries come from the source notes, which do not name the studies behind them.
- Anxiety and palpitations (Hridrava, Chittodvega): traditionally used to calm the heart and mind.
- Gastric disorders (Amlapitta, Parinamashoola): traditionally used as an antacid. A preclinical study reported anti-ulcerogenic activity.
What do recent studies show?
- Balkrishna A, Sinha S, Shukla S and others 2025. Anti-ulcerogenic activity of the marine-pearl derived medicine mukta Pishti in Rat model of pylorus ligation-induced peptic ulcer. Journal of ethnopharmacology. PMID 39828143 · doi:10.1016/j.jep.2025.119378
Mukta Pishti treatment significantly reduced ulcer index in stomach region and protected against epithelial damages, hemorrhages, and edema induced by pylorus ligation. Demonstrated gastroprotective properties through multiple mechanisms.
Only studies that could be traced to a published paper are listed here. An absence here means we could not identify the source, not that no work exists.
Recent safety updates
- Mukta Pishti is pearl-derived and is not formulated with heavy metals (mercury, arsenic, lead); it is essentially a processed natural calcium preparation
- Safety in pregnancy not established; used traditionally for pregnancy-related Pitta conditions under physician guidance
- Dose-dependent caution: Exceeding 250 mg twice daily may cause bloating, constipation, or calcium imbalance; maximum recommended daily dose should not exceed 500 mg
- Quality control concern: Without proper Shodhana, impurities like sharp undissolved particles can damage GI lining - always use authenticated, laboratory-tested products from GMP-certified manufacturers
What is it made of?
Mineral/Elemental Profile
- Calcium carbonate (CaCO3): Major component (pearl-derived, >90%)
- Calcium (Ca): ~38%
- Conchiolin protein: Trace (organic matrix)
- Strontium (Sr): Trace
- Magnesium (Mg): Trace
Dosage forms and preparation
Dosage Forms: Pishti, Bhasma (Mukta Bhasma also available)
Standard Dosage: 60–125 mg twice daily (Pishti); Bhasma: 30–60 mg
Optimal Timing: With honey, Malai, or Gulkand; best taken at bedtime for calming effect
Storage: Airtight glass container; cool, dry place
Marker Compounds: Calcium carbonate (aragonite), Conchiolin protein, Magnesium, Strontium, Trace minerals
Vehicle (Anupana): Honey, Malai (cream of milk), Gulkand, or pomegranate juice
Stability Notes
Stable indefinitely if kept dry. Aragonite crystal structure maintained in Pishti; converts to calcite in Bhasma (heat-processed)
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Laboratory and animal studies1
- 2025. Anti-ulcerogenic activity of the marine-pearl derived medicine mukta Pishti in Rat model of pylorus ligation-induced peptic ulcerJournal of ethnopharmacology. PMID 39828143 · doi:10.1016/j.jep.2025.119378
Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.
Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.
Educational reference only. Nothing on this page is medical advice, a diagnosis, or a recommendation to take anything. Traditional uses and research findings are reported as published, not as claims about what any product does. If you take prescribed medication, raise any interaction with the prescriber rather than acting on a page. See our editorial standards.