Mukta Pishti
Mukta Pishti is a bhasma, a mineral or metal preparation reduced to ash by repeated calcination. [Anti-ulcerogenic activity of the marine-pearl derived medicine mukta Pishti in Rat model of pylorus ligation-induced peptic ulcer](https://pubmed.ncbi.nlm.nih.gov/39828143/).
| Substance type | Mineral or metal preparation, not a plant |
|---|---|
| Also known as | Mukta Pishti, MuktaPishti |
Names and identification
| Language | Name |
|---|---|
| English | Mukta Pishti |
How does it work?
- Acid-neutralizing and gastroprotective: Calcium carbonate (aragonite form) directly neutralizes gastric acid; the ultra-fine particle size from traditional trituration enhances surface area and buffering capacity
- Anxiolytic and cardiac calming: Conchiolin peptides may cross the blood-brain barrier and modulate GABAergic and serotonergic neurotransmission; calcium supplementation stabilizes cardiac rhythm, reducing palpitations
- Pitta-pacifying cooling action: The high calcium content combined with organic pearl matrix provides systemic cooling effect; reduces cortisol (stress hormone) levels, attenuating stress and improving sleep
- Bone mineralization support: Bioavailable calcium from aragonite form is absorbed and contributes to bone mineral density
Which traditional uses are supported by research?
- Anxiety and palpitations (Hridrava, Chittodvega): Clinical practice evidence and mechanistic rationale (calcium-mediated cardiac stabilization, conchiolin peptide neurotransmitter modulation) support the traditional use for heart and mind calming
- Gastric disorders (Amlapitta, Parinamashoola): 2025 preclinical study validated anti-ulcerogenic activity; the calcium carbonate-based acid neutralization mechanism directly supports the traditional antacid use
What do recent clinical trials show?
- Balkrishna A, Sinha S, Shukla S and others 2025. Anti-ulcerogenic activity of the marine-pearl derived medicine mukta Pishti in Rat model of pylorus ligation-induced peptic ulcer. Journal of ethnopharmacology. PMID 39828143 · doi:10.1016/j.jep.2025.119378
Mukta Pishti treatment significantly reduced ulcer index in stomach region and protected against epithelial damages, hemorrhages, and edema induced by pylorus ligation. Demonstrated gastroprotective properties through multiple mechanisms.
1 further claim previously listed here could not be traced to a published paper and has been removed. An absence here means we could not identify the source, not that no work exists.
Recent safety updates
- GENERALLY SAFE: Mukta Pishti is one of the safest Ayurvedic mineral preparations as it contains no heavy metals (mercury, arsenic, lead) - it is essentially a processed natural calcium supplement
- Likely safe in pregnancy at recommended doses; used traditionally for pregnancy-related Pitta conditions under physician guidance
- Dose-dependent caution: Exceeding 250 mg twice daily may cause bloating, constipation, or calcium imbalance; maximum recommended daily dose should not exceed 500 mg
- Quality control concern: Without proper Shodhana, impurities like aragonite microshards can damage GI lining - always use authenticated, laboratory-tested products from GMP-certified manufacturers
What is it made of?
Mineral/Elemental Profile
- Calcium carbonate (CaCO3): Major component (pearl-derived, >90%)
- Calcium (Ca): ~38%
- Conchiolin protein: Trace (organic matrix)
- Strontium (Sr): Trace
- Magnesium (Mg): Trace
Analytical Methods: XRD, FTIR, ICP-OES, SEM
Dosage forms and preparation
Dosage Forms: Pishti, Bhasma (Mukta Bhasma also available)
Standard Dosage: 60–125 mg twice daily (Pishti); Bhasma: 30–60 mg
Bioavailability: Excellent; nacre calcium carbonate (aragonite) with protein matrix — 3× more bioavailable than limestone calcium
Optimal Timing: With honey, Malai, or Gulkand; best taken at bedtime for calming effect
Standardized Extract: Pearl pishti — cold-processed natural pearl preparation
Shelf Life: Indefinite
Storage: Airtight glass container; cool, dry place
Marker Compounds: Calcium carbonate (aragonite 82–86%), Conchiolin protein (3–5%), Magnesium, Strontium, Trace minerals
Quality Parameters: Calcium >30%, particle size <25 μm, nacre structure preserved (XRD verification), no synthetic pearl
Vehicle (Anupana): Honey, Malai (cream of milk), Gulkand, or pomegranate juice
Stability Notes
Stable indefinitely if kept dry. Aragonite crystal structure maintained in Pishti; converts to calcite in Bhasma (heat-processed)
Generated for the AgeAyurveda Herb Catalogue
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Laboratory and animal studies1
- 2025. Anti-ulcerogenic activity of the marine-pearl derived medicine mukta Pishti in Rat model of pylorus ligation-induced peptic ulcerJournal of ethnopharmacology. PMID 39828143 · doi:10.1016/j.jep.2025.119378
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