Karpasa Moola
Gossypium herbaceum
Karpasa Moola (Gossypium herbaceum) is a plant used in Ayurveda. Decoction form pre-hydrolyzes glycosides improving aglycone absorption. Milk as Anupana (vehicle) enhances lipophilic constituent absorption and provides buffering action. Gossypol content in roots is significantly lower than seeds.
| Botanical name | Gossypium herbaceum |
|---|---|
| Family | Malvaceae · other entries in this family |
| Order | Malvales |
| Also known as | Karpasa Moola, KarpasaMoola |
| Taxon identifiers | GBIF 3152658 · Wikidata Q177615 · NCBI Taxonomy 34274 |
Names and identification
| Language | Name |
|---|---|
| English | Karpasa Moola |
Ayurvedic pharmacology (Dravyaguna)
| Property | Value | Description |
|---|---|---|
| Rasa (Taste) | Madhura | Primary taste |
| Guna (Quality) | Snigdha | Physical quality |
| Virya (Potency) | Ushna | Heating/Cooling effect |
| Vipaka (Post-digestive) | Madhura | Post-digestive effect |
Dosage forms and preparation
Dosage Forms: Churna (root powder), Kashayam (decoction), Kwatha (concentrated decoction), Capsule, Phanta (hot infusion)
Standard Dosage: 3-6 g root powder twice daily with warm milk; 50-100 mL decoction twice daily
Bioavailability: Root-specific betaine and flavonoid glycosides show moderate oral bioavailability. Decoction form pre-hydrolyzes glycosides improving aglycone absorption. Milk as Anupana (vehicle) enhances lipophilic constituent absorption and provides buffering action. Gossypol content in roots is significantly lower than seeds.
Optimal Timing: After meals with warm milk for galactagogue and uterine tonic applications; before meals for digestive indications
Standardized Extract: Standardized to minimum 2% total flavonoids (as gossypetin equivalents); gossypol content <0.01% for safe internal use
Shelf Life: 24 months for powder; 18 months for capsules; decoction consumed within 24 hours
Storage: Store in airtight containers at 15-30°C. Protect from moisture and insect infestation. Root material is prone to fungal contamination — monitor aflatoxin levels.
Marker Compounds: Gossypetin, Herbacetin, Betaine, Beta-sitosterol, Gossypol (trace — must be quantified), Friedelin
Extraction Methods
- Water decoction (traditional — reduced to 1/4th)
- Hydroalcoholic extraction (50% ethanol)
- Cold maceration for thermolabile constituents
- Reflux extraction with aqueous ethanol
Synergistic Combinations
- Ashoka bark for uterine tonic synergy
- Shatavari for galactagogue enhancement
- Dashamoola for anti-inflammatory root combination
- Bala for strength and uterine support
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Laboratory and animal studies11
- 2023. The Gossypium herbaceum L. Wagad genome as a resource for understanding cotton domesticationG3 (Bethesda, Md.). PMID 36454094 · doi:10.1093/g3journal/jkac308
- 2021. Induction of polyploidy through colchicine in cotton (Gossypium herbaceum) and its conformity by cytology and flow cytometry analysesJournal of genetics. PMID 34344844
- 2020. Genome sequence of Gossypium herbaceum and genome updates of Gossypium arboreum and Gossypium hirsutum provide insights into cotton A-genome evolutionNature genetics. PMID 32284579 · doi:10.1038/s41588-020-0607-4
- 2020. Morphological description of a novel synthetic allotetraploid(A1A1G3G3) of Gossypium herbaceum L.and G.nelsonii Fryx. suitable for disease-resistant breeding applicationsPloS one. PMID 33270669 · doi:10.1371/journal.pone.0242620
- 2018. Transcriptomic profiling of developing fiber in levant cotton (Gossypium herbaceum L.)Functional & integrative genomics. PMID 29332190 · doi:10.1007/s10142-017-0586-4
- 2017. Anti-diabetic and hypolipidemic effects of extract from the seed of Gossypium herbaceum L. in Alloxan-induced diabetic rabbitsPakistan journal of pharmaceutical sciences. PMID 28603116
- 2017. A New Sythetic Hybrid (A1D5) between Gossypium herbaceum and G. raimondii and Its Morphological, Cytogenetic, Molecular CharacterizationPloS one. PMID 28187145 · doi:10.1371/journal.pone.0169833
- 2017. Assessment of Gene Flow Between Gossypium hirsutum and G. herbaceum: Evidence of Unreduced Gametes in the Diploid ProgenitorG3 (Bethesda, Md.). PMID 28546386 · doi:10.1534/g3.117.041509
- 2015. Construction of cytogenetic map of Gossypium herbaceum chromosome 1 and its integration with genetic mapsMolecular cytogenetics. PMID 25628758 · doi:10.1186/s13039-015-0106-y
- 2012. Development and characterization of genomic and expressed SSRs for levant cotton (Gossypium herbaceum L.)TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. PMID 22038488 · doi:10.1007/s00122-011-1729-y
- 1861. Gossypium Herbaceum (Cotton)Atlanta medical and surgical journal. PMID 35826480
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