Granthiparni
Leonotis nepetifolia
Granthiparni (Leonotis nepetifolia) is a plant used in Ayurveda. Limited modern dosage data - follow classical text guidelines. Bioavailability: Leonotis nepetifolia / Granthiparni (in some traditions identified with other species) - limited modern pharmacokinetic data.
| Botanical name | Leonotis nepetifolia |
|---|---|
| Identity source | Ayurvedic Pharmacopoeia of India, Part I, Vol. III: GRANTHIPARNI (Root) |
| Also called | Leonotis nepetaefolia (R.Br.) W.T.Aiton (nomenclatural synonym) Angelica glauca Edgw. (attribution recorded without a cited source) |
| Family | Lamiaceae · other entries in this family |
| Order | Lamiales |
| Taxon identifiers | GBIF 4924659 · Wikidata Q2512194 · NCBI Taxonomy 483799 |
Names and identification
| Language | Name |
|---|---|
| English | Granthiparni |
Ayurvedic pharmacology (Dravyaguna)
| Property | Value | Description |
|---|---|---|
| Rasa (Taste) | Katu, Tikta | Primary taste |
| Guna (Quality) | Laghu, Tikshna | Physical quality |
| Virya (Potency) | Ushna | Heating/Cooling effect |
| Vipaka (Post-digestive) | Katu | Post-digestive effect |
Dosage forms and preparation
Dosage Forms: Churna (powder), Kashayam (decoction), Swarasa (fresh juice), Lepa (external paste), Taila (medicated oil)
Standard Dosage: 3-5g powder twice daily; 50-100ml decoction twice daily; 10-15ml fresh juice; external application as needed. Limited modern dosage data - follow classical text guidelines.
Bioavailability: Leonotis nepetifolia / Granthiparni (in some traditions identified with other species) - limited modern pharmacokinetic data. Contains diterpenoids (leonotinin-type), flavonoids, and iridoids. Diterpenoids from Lamiaceae family typically have moderate oral bioavailability (20-40%). Traditional preparations as Kashayam and Swarasa optimize water-soluble constituent extraction. Limited data necessitates conservative dosing recommendations. Enhancement strategies: standard approaches for diterpenoid-rich herbs (lipid-based formulations, piperine co-administration).
Optimal Timing: Before meals with warm water as per classical guidelines; external paste applied 2-3 times daily to affected areas
Standardized Extract: No widely standardized extract available. Hydroalcoholic extract characterized by HPTLC fingerprint, total phenolic content NLT 2% (as gallic acid equivalent), and total flavonoid content. Develop in-house reference standard from authenticated material.
Shelf Life: Fresh juice: use within 6 hours; 1.5 years (powder); 2 years (tablet if formulated); 2 years (Taila)
Storage: Airtight containers in cool, dry place below 25 deg C. Limited stability data - conduct accelerated stability studies for any commercial formulation. Protect from moisture and light.
Marker Compounds: Diterpenoids (leonotinin-type, if Leonotis sp.), Flavonoids, Iridoids, Beta-sitosterol, Ursolic acid
Extraction Methods
- Fresh plant juice expression (Swarasa)
- Aqueous decoction
- Hydroalcoholic extraction (60:40 ethanol:water)
- Sesame oil processing for Taila
Synergistic Combinations
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