Dhatri Loha
Dhatri Loha is a bhasma, a mineral or metal preparation reduced to ash by repeated calcination. Iron deficiency anemia (Pandu Roga) - validated in multiple clinical trials showing significant hemoglobin improvement (1.5-2 g/dL rise over 8 weeks) Digestive disorders with acid peptic symptoms - traditional use supported by the gastroprotective action of Amalaki and Yashtimadhu components
| Substance type | Mineral or metal preparation, not a plant |
|---|---|
| Also known as | Dhatri Loha, DhatriLoha |
| Pharmacopoeia status | Listed in Ayurvedic Formulary of India (AFI); recognized as classical Ayurvedic medicine under CCRAS (Central Council for Research in Ayurvedic Sciences), Ministry of AYUSH, Government of India |
Names and identification
| Language | Name |
|---|---|
| English | Dhatri Loha |
Where is it described in the classical texts?
Bhaishajya Ratnavali, Shoolaroga Adhikara, Chapter 30, Verses 142-147; also referenced in Rasaratna Samuchaya
How does it work?
- Loha Bhasma provides bioavailable nano-particulate iron (Fe3O4/gamma-Fe2O3, ~34 nm) for direct hemoglobin synthesis and erythropoiesis
- Amalaki (Emblica officinalis) is rich in vitamin C, markedly enhancing non-heme iron absorption in the GI tract and acting as a potent antioxidant
- Yashtimadhu (licorice) provides gastroprotective and anti-inflammatory effects, reducing GI irritation from iron supplementation
- Guduchi (Tinospora cordifolia) has immunomodulatory and hepatoprotective properties, supporting liver function for optimal iron metabolism
- Ushna virya (mildly heating potency) of Loha Bhasma kindles Agni (digestive fire), transforming Ama (metabolic toxins) and improving Dhatu (tissue) nourishment
Which traditional uses are supported by research?
- Iron deficiency anemia (Pandu Roga) - validated in multiple clinical trials showing significant hemoglobin improvement (1.5-2 g/dL rise over 8 weeks)
- Digestive disorders with acid peptic symptoms - traditional use supported by the gastroprotective action of Amalaki and Yashtimadhu components
What do recent clinical trials show?
- Srikanth N, Rao BC, Yadav B and others 2021. Dhatri Lauha in the management of iron deficiency anemia: A prospective open-label single-arm multi-center trial. Ayu. PMID 37153071 · doi:10.4103/ayu.ayu_379_21
Multi-center trial across 12 centers (40 participants/site) showed Dhatri Lauha 500 mg twice daily for 45 days significantly improved hemoglobin, RBC, and iron metabolism parameters in IDA patients; well tolerated and clinically safe
2 further claims previously listed here could not be traced to a published paper and have been removed. An absence here means we could not identify the source, not that no work exists.
Recent safety updates
- Multi-center trial (2023) confirmed Dhatri Lauha is well tolerated with no significant adverse effects at 500 mg twice daily for 45 days
- Prolonged unsupervised use may lead to iron overload (hemochromatosis-like symptoms) - serum ferritin monitoring recommended beyond 8 weeks
- Contraindicated in patients with hemochromatosis, thalassemia major, or conditions with existing iron overload
- Loha Bhasma toxicity study showed safety at therapeutic dose and 5x therapeutic dose; only at highest doses were biochemical alterations evident, confirming dose-dependent safety profile
- Heavy metal contaminant testing should confirm compliance with API limits for lead, arsenic, and mercury
What is it made of?
Mineral/Elemental Profile
- Primary component: Mineral-derived preparation
- Note: Composition varies by specific preparation method
Analytical Methods: XRD, ICP-OES, SEM-EDS
Dosage forms and preparation
Dosage Forms: Vati/tablet
Standard Dosage: 250–500 mg (1–2 tablets) twice daily
Bioavailability: Enhanced iron absorption due to Amla (Dhatri) vitamin C content facilitating Fe3+ → Fe2+ conversion
Optimal Timing: After meals with honey or warm water
Standardized Extract: Iron bhasma combined with Amla and Triphala
Shelf Life: 3–5 years
Storage: Airtight container; cool, dry place
Marker Compounds: Iron oxide (from Loha Bhasma), Ascorbic acid/tannins (from Dhatri), Triphala polyphenols
Quality Parameters: Iron content as labeled, disintegration <30 min, hardness 4–6 kg/cm², uniformity of weight ±5%
Vehicle (Anupana): Honey, warm water, or Amla juice
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Laboratory and animal studies1
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