Dadrughna
Dadrughna is a substance used in the Ayurvedic materia medica. Oil-based formulations (Taila) enhance dermal penetration of lipophilic actives. For internal use, limited pharmacokinetic data available. Traditional practice emphasizes external application. Enhancement: incorporation into liposomal gels or nanostructured lipid carriers for improved dermal delivery.
| Substance type | Identity unsettled: the sources disagree on what this drug is, so no botanical name is given |
|---|
Names and identification
| Language | Name |
|---|---|
| English | Dadrughna |
Ayurvedic pharmacology (Dravyaguna)
| Property | Value | Description |
|---|---|---|
| Rasa (Taste) | Katu | Primary taste |
| Guna (Quality) | Laghu, Ruksha | Physical quality |
| Virya (Potency) | Ushna | Heating/Cooling effect |
| Vipaka (Post-digestive) | Katu | Post-digestive effect |
What is it made of?
Mineral/Elemental Profile
- Primary component: Mineral-derived preparation
- Note: Composition varies by specific preparation method
Analytical Methods: XRD, ICP-OES, SEM-EDS
Dosage forms and preparation
Dosage Forms: Lepa (topical paste), Taila (medicated oil), Churna (powder), Kashayam (decoction for external wash), Ointment
Standard Dosage: External use: paste applied to affected area 2-3 times daily; Internal: 3-5g powder twice daily with honey or warm water (limited internal use data)
Bioavailability: Primarily used topically; percutaneous absorption of antifungal constituents depends on vehicle and skin integrity. Oil-based formulations (Taila) enhance dermal penetration of lipophilic actives. For internal use, limited pharmacokinetic data available. Traditional practice emphasizes external application. Enhancement: incorporation into liposomal gels or nanostructured lipid carriers for improved dermal delivery.
Optimal Timing: Topical application after bathing on clean, dry skin; internal use before meals if prescribed
Standardized Extract: Aqueous or hydroalcoholic extract standardized by TLC fingerprint and total phenolic content (NLT 3% as gallic acid equivalent). Extract ratio 5:1 typical.
Shelf Life: 1 year (powder); 1.5 years (ointment); 2 years (Taila/medicated oil)
Storage: Cool, dry place away from direct sunlight. Topical preparations stored below 30 deg C. Fresh paste to be used within 24 hours of preparation.
Marker Compounds: Total phenolics (gallic acid equivalents), Flavonoids, Anthraquinones (where applicable)
Extraction Methods
- Cold-pressed juice of fresh plant
- Aqueous paste (Kalka) preparation
- Sesame oil-based Taila Paka (traditional oil processing)
- Hydroalcoholic extraction (70:30)
Synergistic Combinations
- With Karanja (Pongamia) oil for enhanced antifungal action
- With Haridra (turmeric) for anti-inflammatory and antimicrobial synergy
- With Nimba (neem) for broad-spectrum dermatological use
- With Chakramarda (Cassia tora) for ringworm treatment
Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.
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