Bhunimba
Bhunimba is a substance used in the Ayurvedic materia medica. Extensive first-pass metabolism via CYP3A4 and CYP2C9. Nanoparticle formulations improve bioavailability by 2-4x. Andrographolide-phospholipid complex (phytosome) shows significantly improved Cmax. Self-nanoemulsifying systems show promising results in preclinical studies.
Names and identification
| Language | Name |
|---|---|
| English | Bhunimba |
Ayurvedic pharmacology (Dravyaguna)
| Property | Value | Description |
|---|---|---|
| Rasa (Taste) | Tikta | Primary taste |
| Guna (Quality) | Laghu | Physical quality |
| Virya (Potency) | Sheeta | Heating/Cooling effect |
| Vipaka (Post-digestive) | Katu | Post-digestive effect |
What is it made of?
Mineral/Elemental Profile
- Primary component: Mineral-derived preparation
- Note: Composition varies by specific preparation method
Analytical Methods: XRD, ICP-OES, SEM-EDS
Dosage forms and preparation
Dosage Forms: Churna (powder), Tablet, Capsule, Kashayam (decoction), Kwath Ghana (solid extract), Vati (traditional pill), Asava
Standard Dosage: 1-3g powder twice daily; 300-500mg standardized extract; 50-100ml decoction; traditionally used in small doses due to intense bitterness
Bioavailability: Andrographolide shows moderate oral bioavailability (25-35%) with rapid absorption (Tmax 1.5-2h). Extensive first-pass metabolism via CYP3A4 and CYP2C9. Nanoparticle formulations improve bioavailability by 2-4x. Andrographolide-phospholipid complex (phytosome) shows significantly improved Cmax. Self-nanoemulsifying systems show promising results in preclinical studies.
Optimal Timing: Before meals with warm water for fever and infections; with honey for bitter taste mitigation; empty stomach for maximum absorption
Standardized Extract: Whole plant extract standardized to andrographolide NLT 10% (concentrated extract); NLT 30% for high-potency capsules. Total diterpene lactones NLT 15%.
Shelf Life: 2 years (powder); 3 years (tablet/capsule); 1 year (decoction)
Storage: Cool, dry place away from light. Andrographolide is light-sensitive—use amber containers. Temperature below 25°C for extract-based products.
Marker Compounds: Andrographolide, Neoandrographolide, 14-deoxy-11,12-didehydroandrographolide, Andrograpanin, Andrographiside, Kalmeghin
Extraction Methods
- Hydroalcoholic extraction (80:20 ethanol:water) for andrographolide enrichment
- Aqueous decoction for traditional Kashayam
- Methanol extraction for maximum diterpenoid yield
- Supercritical CO2 for high-purity andrographolide
- Spray drying with maltodextrin carrier for stable powder extract
Synergistic Combinations
- With Guduchi for immunomodulatory and antipyretic synergy
- With Kutki for hepatoprotective formulations
- With Neem for antimicrobial and blood-purifying effects
- With Chirayata for Jwara (fever) management
- With Haridra for anti-inflammatory combinations
Available from Age Ayurveda
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Immuno PlusA seven-herb blend traditionally used to support immune function.
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