Amlaparni
Oxalis corniculata L.
Amlaparni (Oxalis corniculata L.) is a plant used in Ayurveda, from the Oxalidaceae family. Not listed in WHO monographs on selected medicinal plants; incorporated into approved Chinese patent medicines indicating regulatory acceptance in some traditional medicine systems.
| Botanical name | Oxalis corniculata L. |
|---|---|
| Family | Oxalidaceae · other entries in this family |
| Order | Oxalidales |
| Pharmacopoeia status | Not listed in WHO monographs on selected medicinal plants; incorporated into approved Chinese patent medicines indicating regulatory acceptance in some traditional medicine systems |
| Taxon identifiers | GBIF 8427624 · Wikidata Q162795 · NCBI Taxonomy 212256 |
This entry and changeri describe the same drug, Oxalis corniculata, under different names. Both pages are kept because both names are in use; the other is treated as the primary record for citation.
Names and identification
| Language | Name |
|---|---|
| English | Amlaparni |
| Latin/Botanical | Oxalis corniculata L. |
Key Phytochemical Constituents
- Vitexin-2-O-beta-D-glucopyranoside
- Isovitexin
- Beta-sitosterol
- Betulin
- Apigenin
- Oxalic acid
- 4-Hydroxybenzoic acid
- Ethyl gallate
- Stearic acid
- Palmitic acid
How does it work?
- Flavonoids (vitexin, isovitexin, apigenin) exert antioxidant effects through direct free radical scavenging and chelation of pro-oxidant metal ions, reducing oxidative damage in cellular models
- Beta-sitosterol and betulin modulate inflammatory pathways by inhibiting NF-kB nuclear translocation and reducing expression of pro-inflammatory mediators (COX-2, iNOS, TNF-alpha)
- Ethyl gallate and phenolic compounds exhibit antimicrobial activity by disrupting bacterial cell membrane permeability and inhibiting biofilm formation
Which traditional uses are supported by research?
- Antidiabetic and hypoglycemic activity validated through in vivo studies confirming traditional Ayurvedic use of Amlaparni for managing blood sugar levels
- Wound healing properties confirmed in preclinical models consistent with traditional topical application for skin conditions and wound management in folk medicine
- Hepatoprotective effects demonstrated in animal models supporting traditional use for liver disorders
What do recent clinical trials show?
- Zhong T, He J, Zhao H and others 2025. Oxalis corniculata L. As a Source of Natural Antioxidants: Phytochemistry, Bioactivities, and Application Potential. Antioxidants (Basel, Switzerland). PMID 41300509 · doi:10.3390/antiox14111352
Comprehensive review highlighting flavonoids, polysaccharides, and organic acids as dominant metabolites with antioxidant, anti-inflammatory, antimicrobial, neuroprotective, hypoglycemic, and anticancer effects. - Sarfraz I, Rasul A, Hussain G and others 2022. A Review on Phyto-pharmacology of Oxalis corniculata. Combinatorial chemistry & high throughput screening. PMID 34391377 · doi:10.2174/1386207324666210813121431
Plant demonstrated significant hepatoprotective, antidiabetic, and wound healing activities in preclinical models, supporting traditional ethnomedicinal claims.
1 further claim previously listed here could not be traced to a published paper and has been removed. An absence here means we could not identify the source, not that no work exists.
Recent safety updates
- High oxalic acid content is the primary safety concern; excessive consumption may cause oxalate nephropathy and kidney stone formation in susceptible individuals
- Traditional use suggests safe consumption in small therapeutic doses; no formal toxicity studies with standardized LD50 determination have been completed in human trials
- Should be used cautiously in patients with renal impairment, hyperoxaluria, or history of calcium oxalate kidney stones; further preclinical and clinical safety trials are recommended
Dosage forms and preparation
Dosage Forms: Churna (powder), Kashayam (decoction), Swarasa (fresh juice), Capsule, Tablet
Standard Dosage: 3-5g powder twice daily; 40-80ml decoction twice daily; 10-20ml fresh juice
Bioavailability: Limited modern pharmacokinetic data. Traditional enhancement with honey, warm water, or Trikatu yoga recommended. The herb’s acidic taste (Amla rasa) suggests presence of organic acids that are generally well absorbed orally.
Optimal Timing: Before meals with warm water for digestive indications; with honey for respiratory conditions
Standardized Extract: Limited standardization data. TLC/HPTLC fingerprinting recommended. Total organic acid content as preliminary quality parameter.
Shelf Life: 18 months (powder); 2 years (capsules/tablets)
Storage: Cool, dry place below 25°C, in airtight containers, protected from moisture and light.
Marker Compounds: Total organic acids, Total phenolics, Total flavonoids, Ascorbic acid (if present)
Extraction Methods
- Aqueous decoction (classical method)
- Hydroalcoholic extraction (60:40)
- Fresh juice expression
- Cold maceration
Synergistic Combinations
- With Amalaki for enhanced sour/astringent synergy
- With Guduchi for immune support
- With Musta for digestive disorders
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Other clinical studies and reviews3
- 2026. Chemical Diversity and Biomedical Relevance of Oxalis corniculata L.: A Review of Nutritional and Pharmacological AspectsChemistry & biodiversity. PMID 41240331 · doi:10.1002/cbdv.202502154
- 2025. Oxalis corniculata L. As a Source of Natural Antioxidants: Phytochemistry, Bioactivities, and Application PotentialAntioxidants (Basel, Switzerland). PMID 41300509 · doi:10.3390/antiox14111352
- 2022. A Review on Phyto-pharmacology of Oxalis corniculataCombinatorial chemistry & high throughput screening. PMID 34391377 · doi:10.2174/1386207324666210813121431
Laboratory and animal studies9
- 2023. From green to red: Urban heat stress drives leaf color evolutionScience advances. PMID 37862418 · doi:10.1126/sciadv.abq3542
- 2022. An acidic polysaccharide from Oxalis corniculata L. and the preliminary study on its antioxidant activityJournal of food biochemistry. PMID 35579221 · doi:10.1111/jfbc.14235
- 2022. Apoptosis Effects of Oxalis corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line:Galen medical journal. PMID 36698692 · doi:10.31661/gmj.v11i.2484
- 2021. Hybridization of Oxalis corniculata and O. dillenii in their non-native rangePhytoKeys. PMID 34054321 · doi:10.3897/phytokeys.178.61031
- 2021. The complete chloroplast genome sequence of Oxalis corniculata (L.)Mitochondrial DNA. Part B, Resources. PMID 33889744 · doi:10.1080/23802359.2021.1878950
- 2020. Complete Chloroplast Genome Characterization of Oxalis Corniculata and Its Comparison with Related Species from Family OxalidaceaePlants (Basel, Switzerland). PMID 32717796 · doi:10.3390/plants9080928
- 2019. The origin of Oxalis corniculata LPeerJ. PMID 30783568 · doi:10.7717/peerj.6384
- 2016. Anticancer activity of Cynodon dactylon and Oxalis corniculata on Hep2 cell lineCellular and molecular biology (Noisy-le-Grand, France). PMID 27188871
- 2015. Ethnomedicinal plants of Kathua district, J&K, IndiaJournal of ethnopharmacology. PMID 26023030 · doi:10.1016/j.jep.2015.05.028
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