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Agnimantha

Premna integrifolia (Clerodendrum phlomidis is also used under this name)

Agnimantha (Premna integrifolia; Clerodendrum phlomidis is also used under this name) is classified in Ayurveda as Shothaghna (Anti-inflammatory), Deepaniya (Appetizer), from the Lamiaceae family. Parts used: root, bark, leaf. Name means 'fire churner': stimulates digestive fire.

Key facts
Botanical namePremna integrifolia (Clerodendrum phlomidis is also used under this name)
Currently accepted namePremna serratifolia L., the name above is treated as a synonym by GBIF; both are in use
FamilyLamiaceae · other entries in this family
OrderLamiales
Ayurvedic categoryShothaghna (Anti-inflammatory), Deepaniya (Appetizer)
Taxon identifiersGBIF 7308606 · Wikidata Q87639631

The evidence at a glance

12papers on this site for this drug, published 1984 to 2026, 11 with a DOI.

  • 2Other clinical studies and reviews
  • 10Laboratory and animal studies

A count is not a conclusion and a tier is a study design, not a verdict. Everything listed here is laboratory or animal work, which does not show an effect in people. Each paper is listed with what it measured on the page below. See the research index for how papers are tiered.

Names and identification

LanguageName
EnglishAgnimantha
Common NamesAgnimantha, Fire churner
HindiArani, Agnimantha
SanskritAgnimantha
Latin/BotanicalPremna integrifolia (Clerodendrum phlomidis is also used under this name)

Parts Used

  • Root
  • Bark
  • Leaf

Ayurvedic pharmacology (Dravyaguna)

PropertyValueDescription
Rasa (Taste)TiktaPrimary taste
Guna (Quality)LaghuPhysical quality
Virya (Potency)UshnaHeating/Cooling effect
Vipaka (Post-digestive)KatuPost-digestive effect

Dosha Effects

DoshaEffect
VataDecreases
KaphaDecreases
PittaMay Increase

Key Phytochemical Constituents

Therapeutic Actions (Karma)

How is it used traditionally?

Name means ‘fire churner’, stimulates digestive fire. One of ten roots in Dashamoola. Used for Shotha (inflammation), Agnimandya (weak digestion), and Amavata (rheumatoid arthritis).

Where is it described in the classical texts?

  • Charaka Samhita (Shothaghna group)
  • Sushruta Samhita

Root powder and decoction: see the Standard Dosage under Dosage forms and preparation.

Safety, contraindications and cautions

  • Pitta conditions
  • Pregnancy

What is it made of?

Part(s) Analyzed: Root, Bark, Leaf

Dosage forms and preparation

Dosage Forms: Churna (powder), Kashayam (decoction), Kwatha tablet, Capsule, Asava-Arishta (fermented preparation), Guggulu combination

Standard Dosage: 3-6g powder twice daily; 50-100ml decoction twice daily; 500mg-1g extract capsule

Optimal Timing: Before meals with warm water for metabolic and digestive indications; with Dashamoola kwatha for inflammatory conditions

Storage: Cool, dry place below 25°C, RH < 60%. Protect from light. Asava-Arishta in amber glass bottles at room temperature.

Marker Compounds: Premnatriol, Prematurrins A-D, 5-Hydroxymethylfurfural, Iridoid glycosides, Agnuside, Beta-sitosterol

Synergistic Combinations

Published research

Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.

Other clinical studies and reviews2

  1. Mali PY. 2016. Pharmacological potentials of Premna integrifolia LAncient science of life. PMID 27143797 · doi:10.4103/0257-7941.179864
  2. Mali PY. 2015. Premna integrifolia L.: A review of its biodiversity, traditional uses and phytochemistryAncient science of life. PMID 26600661 · doi:10.4103/0257-7941.165624

Laboratory and animal studies10

  1. Biradar PR, Naik S, Dwivedi PSR and others. 2026. Neuroprotective effects of Premna integrifolia nano-phytosomes in haloperidol-induced Parkinson's rat model: A computational-guided Olivil nanoformulation delivery approachMetabolic brain disease. PMID 41874857 · doi:10.1007/s11011-026-01821-z
  2. Alsareii SA, Alzerwi NAN, AlAsmari MY and others. 2022. Topical Application of Premna integrifolia Linn on Skin Wound Injury in Rats Accelerates the Wound Healing Process: Evidence from In Vitro and In Vivo Experimental ModelsEvidence-based complementary and alternative medicine : eCAM. PMID 35463068 · doi:10.1155/2022/6449550
  3. Singh C, Upadhyay R, Tiwari KN. 2022. Comparative analysis of the seasonal influence on polyphenolic content, antioxidant capacity, identification of bioactive constituents and hepatoprotective biomarkers by in silico docking analysis in Premna integrifolia LPhysiology and molecular biology of plants : an international journal of functional plant biology. PMID 35221581 · doi:10.1007/s12298-021-01120-0
  4. Singh C, Tiwari KN, Kumar P and others. 2021. Toxicity profiling and antioxidant activity of ethyl acetate extract of leaves of Premna integrifolia L. for its application as protective agent against xenobioticsToxicology reports. PMID 33489779 · doi:10.1016/j.toxrep.2021.01.004
  5. Singh C, Prakash C, Tiwari KN and others. 2018. Premna integrifolia ameliorates cyclophosphamide-induced hepatotoxicity by modulation of oxidative stress and apoptosisBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. PMID 30118879 · doi:10.1016/j.biopha.2018.08.039
  6. Azad R, Babu NK, Gupta AD and others. 2018. Evaluation of anti-inflammatory and immunomodulatory effects of Premna integrifolia extracts and assay-guided isolation of a COX-2/5-LOX dual inhibitorFitoterapia. PMID 30339925 · doi:10.1016/j.fitote.2018.10.016
  7. Khatun H, Majumder R, Al Mamun and others. 2014. Preliminary pharmacological activity of the methanolic extract of Premna integrifolia barks in ratsAvicenna journal of phytomedicine. PMID 25050319
  8. Gokani RH, Lahiri SK, Santani DD and others. 2011. Evaluation of anti-inflammatory and antioxidant activity of Premna integrifolia rootJournal of complementary & integrative medicine. PMID 22754928 · doi:10.2202/1553-3840.1216
  9. Yadav D, Tiwari N, Gupta MM. 2011. Simultaneous quantification of diterpenoids in Premna integrifolia using a validated HPTLC methodJournal of separation science. PMID 21268251 · doi:10.1002/jssc.201000696
  10. Dasgupta B, Sinha NK, Pandey VB and others. 1984. Major Alkaloid and Flavonoid of Premna integrifoliaPlanta medica. PMID 17340317 · doi:10.1055/s-2007-969705

Reference lists that include it

Flavonoids

Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.

Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.

Educational reference only. Nothing on this page is medical advice, a diagnosis, or a recommendation to take anything. Traditional uses and research findings are reported as published, not as claims about what any product does. If you take prescribed medication, raise any interaction with the prescriber rather than acting on a page. See our editorial standards.