Vyoshadi Guggulu
Vyoshadi Guggulu is a classical Ayurvedic guggulu, a resin-based preparation. Listed in Ayurvedic Formulary of India (AFI) Part I. The Ayurvedic Formulary of India (Part I, entry 5:9) lists 10 ingredients: Sunthi 1 part, Marica 1 part, Pippali 1 part, Agni 1 part, Musta 1 part, Haritaki 1 part, Bibhitaka 1 part, Amalaki 1 part, Vidanga 1 part and Guggulu-suddha 9 parts.
| Also known as | Vyoshadi Guggulu, VyoshadiGuggulu |
|---|---|
| Pharmacopoeia status | Listed in Ayurvedic Formulary of India (AFI) Part I; monographed in Ayurvedic Pharmacopoeia of India (API); recognized by CCRAS |
Composition
As given in the Ayurvedic Formulary of India, Part I, entry 5:9 (VYOSADI GUGGULU), which cites Astangahrdaya, Cikitsasthana, Adhyaya 21; 49.. Names, parts and quantities are transcribed as printed and checked row by row against the book. Manufacturers' versions of a classical formulation can differ from the formulary.
| # | Ingredient | Part | Quantity |
|---|---|---|---|
| 1 | Sunthi | rhizome | 1 part |
| 2 | Marica | fruit | 1 part |
| 3 | Pippali | fruit | 1 part |
| 4 | Agni (citraka) | root | 1 part |
| 5 | Musta | rhizome | 1 part |
| 6 | Haritaki | pericarp | 1 part |
| 7 | Bibhitaka | pericarp | 1 part |
| 8 | Amalaki | pericarp | 1 part |
| 9 | Vidanga | fruit | 1 part |
| 10 | Guggulu-suddha | exudate | 9 parts |
The Formulary gives the anupana, the vehicle it is taken with, as warm water. This is what the Formulary records for the classical preparation. It is not a dose for any product, and not advice to take anything.
The evidence at a glance
1paper on this site for this drug, every one with a DOI.
- 1Laboratory and animal studies
A count is not a conclusion and a tier is a study design, not a verdict. Everything listed here is laboratory or animal work, which does not show an effect in people.true See the research index for how papers are tiered.
Names and identification
| Language | Name |
|---|---|
| English | Vyoshadi Guggulu |
Where is it described in the classical texts?
Sharangdhara Samhita (Madhyama Khanda, Chapter 7); also referenced in Bhaishajya Ratnavali (Kasa/Pratishyaya Chikitsa) and Chakradatta; described under the guggulu formulation group for Kapha-Vata disorders
How does it work?
- Thyroid stimulation: Guggulsterones from Guggulu are reported to have thyroid stimulating activity
- Anti-inflammatory cytokine inhibition: Guggulsterones inhibit pro-inflammatory cytokines (TNF-alpha, IL-6) while Trikatu promotes GI absorption of these active compounds
- Respiratory decongestant: Hot potency of Trikatu and Guggulu are classically regarded as reducing Kapha stagnation in the lungs
- Mucosal tonicity: Terminalia fruit tannins (from Triphala) are traditionally regarded as toning mucosal tissue in the respiratory tract
- Metabolic and lipid regulation: Guggulsterones have been reported in laboratory studies to lower cholesterol through FXR antagonism and to stimulate phagocytosis
Which traditional uses are supported by research?
These summaries come from the source notes, which do not name the studies behind them.
- Galaganda (thyroid swelling): traditionally used for thyroid conditions. A randomized controlled trial reported a reduction in TSH levels, with no adverse effects reported.
- Pratishyaya (respiratory congestion and common cold): traditionally used for congestion and colds. A clinical study reported improvement in cough frequency.
- Obesity: used in classical practice for excess weight. A prospective multicenter study reported on the safety and outcomes of Vyoshadi Guggulu combined with Haritaki Churna.
- Voice hoarseness and throat disorders: traditionally used for hoarseness and throat complaints.
What do recent studies show?
No study for this section could be traced to a published paper. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.
Recent safety updates
- Studies summarized in the source notes reported no adverse effects, with LFT and RFT within normal limits and no adverse drug reactions in the treatment groups
- Standard guggulu precautions apply: contraindicated in pregnancy and lactation; may interact with thyroid medications (synergistic effect could cause hyperthyroidism); avoid in bleeding disorders as guggul may slow clotting; discontinue 2 weeks before surgery
What is it made of?
The Ayurvedic Formulary of India recipe, every ingredient with its part and quantity, is in the composition table near the top of this page.
Dosage forms and preparation
Dosage Forms: Vati (pill/tablet), Capsule
Standard Dosage: 2 tablets twice daily
Optimal Timing: After meals, twice daily
Storage: Airtight container, cool dry place; guggulu preparations are hygroscopic
Marker Compounds: Guggulsterone, Piperine, Gingerol
Vehicle (Anupana): Warm water
Synergistic Combinations
- Key herbs: Trikatu (Vyosha), Guggulu, Triphala; guggulu potentiates anti-inflammatory and hypolipidemic actions
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Laboratory and animal studies1
Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.
Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.
Educational reference only. Nothing on this page is medical advice, a diagnosis, or a recommendation to take anything. Traditional uses and research findings are reported as published, not as claims about what any product does. If you take prescribed medication, raise any interaction with the prescriber rather than acting on a page. See our editorial standards.