Panchagavya Ghrita
Panchagavya Ghrita is a classical Ayurvedic ghrita, a medicated ghee. Listed in Ayurvedic Formulary of India (AFI) for Apasmara (epilepsy), Jvara (fever), Unmada (mania), and Kamala (jaundice); standardization based on AFI preparation methods; regulated under Drugs and Cosmetics Act, 1940. The Ayurvedic Formulary of India (Part I, entry 6:25) lists 5 ingredients: Gomaya svarasa, Ksira, Dadhi 3.072kg, Mutra 3.072 and Havi 768 g.
| Also known as | Panchagavya Ghrita, PanchagavyaGhrita |
|---|---|
| Pharmacopoeia status | Listed in Ayurvedic Formulary of India (AFI) for Apasmara (epilepsy), Jvara (fever), Unmada (mania), and Kamala (jaundice); standardization based on AFI preparation methods; regulated under Drugs and Cosmetics Act, 1940 |
Composition
As given in the Ayurvedic Formulary of India, Part I, entry 6:25 (PANCAGAVYA GHRTA), which cites Astangahrdaya, Uttarasthana, Adhyaya 7; 18.. Names, parts and quantities are transcribed as printed and checked row by row against the book. Manufacturers' versions of a classical formulation can differ from the formulary.
| # | Ingredient | Part | Quantity |
|---|---|---|---|
| 1 | Gomaya svarasa | illegible | |
| 2 | Ksira | illegible | |
| 3 | Dadhi (godadhi) * | 3.072kg. | |
| 4 | Mutra (gomutra) * | 3.072 | |
| 5 | Havi (goghrta) | 768 g. |
Cells marked illegible are damaged in the source scan. The ingredient name is shown where it was readable, and nothing is inferred to fill a gap.
* The scanned text was damaged at this row and the name was read from the entry's own Sanskrit verse.
The Formulary gives the anupana, the vehicle it is taken with, as warm milk, warm water. This is what the Formulary records for the classical preparation. It is not a dose for any product, and not advice to take anything.
The evidence at a glance
4papers on this site for this drug, published 2013 to 2026, 3 with a DOI.
- 4Laboratory and animal studies
A count is not a conclusion and a tier is a study design, not a verdict. Everything listed here is laboratory or animal work, which does not show an effect in people.true See the research index for how papers are tiered.
Names and identification
| Language | Name |
|---|---|
| English | Panchagavya Ghrita |
Where is it described in the classical texts?
Sushruta Samhita (mania, epilepsy, fever, hepatitis); Charaka Samhita; Ashtanga Hridaya; Ayurvedic Formulary of India (AFI) Part I, entry 6:25, from Ashtanga Hridaya, Uttarasthana 7; 18 - for Apasmara, Jvara, Unmada, Kamala
How does it work?
- Panchagavya components provide ketogenic substrate through high-fat cow ghee content, mimicking ketogenic diet mechanism in epilepsy management
- Phytochemical profile includes proteins, amino acids, alkaloids, steroids, phenolics, tannins, and flavonoids with antioxidant action reducing oxidative stress in brain
- Studies have reported a possible interaction with conventional anticonvulsants (phenytoin, carbamazepine); anticonvulsant doses should not be changed without medical supervision
Which traditional uses are supported by research?
These summaries come from the source notes, which do not name the studies behind them.
- Apasmara (epilepsy): traditionally used for apasmara. A clinical study reported complete seizure freedom in some patients. Animal studies have reported dose-dependent seizure protection.
- Unmada (psychosis/mania): used in classical practice as a psychiatric indication. Pharmacological studies have reported neuroprotective and GABAergic activity.
- Adjuvant anti-epileptic therapy: studies have reported a synergistic interaction with phenytoin and carbamazepine that allowed dose reduction.
- Kamala (jaundice/liver disorders): traditional hepatoprotective use referenced in Sushruta Samhita
What do recent studies show?
No study for this section could be traced to a published paper. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.
Recent safety updates
- People with diabetes, high cholesterol, and heart disease should exercise precautions
- Very high doses may cause diarrhea and indigestion; cow urine component requires quality-assured sourcing and proper processing per AFI standards
- Interaction potential with conventional anticonvulsants noted - PG may interact with phenytoin and carbamazepine; any dose adjustment only under medical supervision
Dosage forms and preparation
Dosage Forms: Ghrita (medicated ghee), Capsule (for convenience)
Standard Dosage: 6-12ml twice daily for neurological conditions
Optimal Timing: Before meals on empty stomach for best absorption
Storage: Airtight glass/stainless steel container, cool dry place, protected from light and moisture
Marker Compounds: Bacosides, Colostrum proteins
Vehicle (Anupana): Warm water or warm milk
Synergistic Combinations
- The formula is the 5 cow products only, with no herb: cow dung juice, milk, curd, urine and ghee (AFI Part I, entry 6:25); ghee enhances tissue penetration (yogavahi property)
What manufacturers publish about this preparation
Disclosure first. This site is published by Age Ayurveda, which sells Ayurvedic products, though not this preparation. Every cell states what that company's own product page carried when it was read, not our judgement of it. There is no score, no rank and no winner here, and the table is in alphabetical order for that reason.
The formulary entry above fixes the ingredients and the quantity of each. Whether you can check a particular product against it depends on what its manufacturer publishes. Of the 3 companies surveyed that sell a product under this name, this is what their pages carried when they were read on 8 October 2026.
| Company | What its product page publishes |
|---|---|
| Kerala Ayurveda | An ingredient list, without quantities |
| Sitaram Ayurveda | Neither an ingredient list nor quantities |
| The Arya Vaidya Pharmacy, Coimbatore | Neither an ingredient list nor quantities |
This measures what each company publishes, not the quality of anything it makes. A company that publishes nothing here may make an excellent preparation, and the label in the box is a separate, regulated surface that is not what was read. What disclosure changes is whether a reader, a pharmacist or an answer engine can check a product against the formulary entry it claims.
Method, the full counts across every company surveyed, and what this measurement got wrong the first time: which manufacturers publish what is in the bottle. The URL of every page read is recorded in brand-disclosure.json. If a row here is wrong, including where the correction favours a company other than ours, tell us and we will fix it and say that we did. How the same companies' stated doses compare with the formulary dose, preparation by preparation: Ayurvedic company doses against the Ayurvedic Formulary of India.
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Laboratory and animal studies4
- 2015. Panchagavya Ghrita, an Ayurvedic formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in ratsIndian journal of experimental biology. PMID 26245029
- 2015. Pharmacodynamic and pharmacokinetic interaction of Panchagavya Ghrita with phenytoin and carbamazepine in maximal electroshock induced seizures in ratsAyu. PMID 27011723 · doi:10.4103/0974-8520.175538
- 2013. Trividha Snehapaka of Panchagavya Ghrita: A critical comparative evaluationJournal of Ayurveda and integrative medicine. PMID 23930043 · doi:10.4103/0975-9476.113887
- 2026. In silico investigation of Panchagavya Ghrita's anticancer potential against glioblastoma: a network pharmacology and molecular docking studyJournal of receptor and signal transduction research. PMID 42322259 · doi:10.1080/10799893.2026.2689329
Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.
Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.
Educational reference only. Nothing on this page is medical advice, a diagnosis, or a recommendation to take anything. Traditional uses and research findings are reported as published, not as claims about what any product does. If you take prescribed medication, raise any interaction with the prescriber rather than acting on a page. See our editorial standards.