Vriddhadaru
Argyreia nervosa
Vriddhadaru (Argyreia nervosa) is a plant drug, from the Convolvulaceae family. Friedelin and other triterpenoids have low oral bioavailability (<10%) improved by lipid co-administration. Flavonoids (kaempferol, quercetin glycosides) undergo typical Phase II conjugation with moderate bioavailability (~15-20%).
| Botanical name | Argyreia nervosa |
|---|---|
| Family | Convolvulaceae · other entries in this family |
| Order | Solanales |
| Taxon identifiers | GBIF 2928692 · Wikidata Q383947 · NCBI Taxonomy 139741 |
The evidence at a glance
12papers on this site for this drug, published 2003 to 2025, every one with a DOI.
- 2Other clinical studies and reviews
- 10Laboratory and animal studies
A count is not a conclusion and a tier is a study design, not a verdict. Everything listed here is laboratory or animal work, which does not show an effect in people. Each paper is listed with what it measured on the page below. See the research index for how papers are tiered.
Names and identification
| Language | Name |
|---|---|
| English | Vriddhadaru |
Ayurvedic pharmacology (Dravyaguna)
| Property | Value | Description |
|---|---|---|
| Rasa (Taste) | Madhura, Tikta | Primary taste |
| Guna (Quality) | Laghu, Snigdha | Physical quality |
| Virya (Potency) | Ushna | Heating/Cooling effect |
| Vipaka (Post-digestive) | Madhura | Post-digestive effect |
Dosage forms and preparation
Dosage Forms: Churna (powder), Kwatha (decoction), Capsule, Tablet, Taila (medicated oil), Lepa (paste)
Standard Dosage: 3-6 g powder twice daily; 50-100 mL decoction twice daily; external oil application as needed
Optimal Timing: After meals for internal use; external oil application at night before sleep for musculoskeletal conditions
Storage: Airtight, moisture-proof containers at 15-25 deg C. Medicated oil in amber glass. Protect from light and humidity.
Marker Compounds: Argyrein, Friedelin, Quercetin, Kaempferol, beta-Sitosterol, Scopoletin, Caffeic acid
Synergistic Combinations
- Shunthi (ginger) - anti-inflammatory and digestive synergy
- Ashwagandha - musculoskeletal strength combination
- Bala (Sida cordifolia) - Vata-pacifying musculoskeletal formula
- Eranda Taila (castor oil) - vehicle for Vata disorders
- Guggulu - anti-inflammatory synergy for joint conditions
Published research
Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.
Other clinical studies and reviews2
- 2020. Biomedical analysis of New Psychoactive Substances (NPS) of natural originJournal of pharmaceutical and biomedical analysis. PMID 31704129 · doi:10.1016/j.jpba.2019.112945
- 2017. Herbal Highs: Review on Psychoactive Effects and NeuropharmacologyCurrent neuropharmacology. PMID 27799032 · doi:10.2174/1570159X14666161031144427
Laboratory and animal studies10
- 2025. Argyreia nervosa (Brum.f.) Bojer. alleviates diabetes mellitus-induced male infertilityMolecular biology reports. PMID 40465059 · doi:10.1007/s11033-025-10654-5
- 2024. Argyreia nervosa-driven biosynthesis of Cu-Ag bimetallic nanoparticles from plant leaves extract unveils enhanced antibacterial propertiesBioprocess and biosystems engineering. PMID 38698218 · doi:10.1007/s00449-024-03020-5
- 2023. Estimation of Scopoletin from Roots of Argyreia nervosa (Burm. fill.) Bojer Using a Validated HPLC-Fluorescence Method Optimized Using the Design of Experiment ApproachJournal of AOAC International. PMID 36707989 · doi:10.1093/jaoacint/qsad018
- 2022. Aphrodisiac and spermatogenic potential of alkaloidal fraction of Argyreia nervosa (Burm. f.) Bojer roots in male ratsNatural product research. PMID 33426924 · doi:10.1080/14786419.2020.1869231
- 2022. Beneficial effects of roots of Argyreia nervosa (Brum.f.) Bojer on testosterone biosynthesis in testis and spermatogenesis in Wistar ratsJournal of ethnopharmacology. PMID 35074455 · doi:10.1016/j.jep.2022.115025
- 2018. Argyreia nervosa exposures reported to Texas poison centersJournal of addictive diseases. PMID 31305228 · doi:10.1080/10550887.2019.1640057
- 2014. Identification of legal highs--ergot alkaloid patterns in two Argyreia nervosa productsForensic science international. PMID 25036782 · doi:10.1016/j.forsciint.2014.06.025
- 2013. Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approachesJournal of ethnopharmacology. PMID 23665164 · doi:10.1016/j.jep.2013.04.044
- 2011. Wound healing activity of Argyreia nervosa leaves extractInternational journal of applied & basic medical research. PMID 23776770 · doi:10.4103/2229-516X.81978
- 2003. Argyroside from Argyreia nervosa seedsDie Pharmazie. PMID 12622256 · doi:10.1002/chin.200321168
Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.
Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.
Educational reference only. Nothing on this page is medical advice, a diagnosis, or a recommendation to take anything. Traditional uses and research findings are reported as published, not as claims about what any product does. If you take prescribed medication, raise any interaction with the prescriber rather than acting on a page. See our editorial standards.