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Mandukparni

Centella asiatica

Mandukparni (Centella asiatica) is a plant drug, also called Manduki, Brahma mamduki and Mandukaparni. Triterpene glycosides are hydrolyzed to aglycones (asiatic acid, madecassic acid) which are better absorbed. Lipid-based formulations (Ghrita, phospholipid complexes) increase bioavailability 2-3 fold.

Key facts
Botanical nameCentella asiatica
FamilyApiaceae · other entries in this family
OrderApiales
Taxon identifiersGBIF 3034128 · Wikidata Q324714 · NCBI Taxonomy 48106
Names in other languages
Sanskritमाण्डूकी (māṇḍūkī)
Hindiब्रह्म मंडुकी (brahma maṃḍukī), मण्डूकपर्णी (maṇḍūkaparṇī)
Tamilவல்லாரை

Sources: Ayurvedic Pharmacopoeia of India, MANDUKAPARNI (Whole Plant) monograph on Centella asiatica (title name, Sanskrit synonyms "Manduki, Darduracchada"); MMPND Centella page, which lists "Maṇḍūkaparṇī" under SANSKRIT and "ब्रह्म मंडुकी Brahma maṇḍukī / ब्रहमामानडुकी Brahma manduki" under HINDI.; Ayurvedic Pharmacopoeia of India, MANDUKAPARNI monograph, Sanskrit "Manduki, Darduracchada".; Ayurvedic Pharmacopoeia of India, MANDUKAPARNI monograph, Tamil "Vallarai"; MMPND Centella page, Tamil line "வல்லாரை Vallaarai [Siv] (Vallarai)".; MMPND Centella page, Hindi line "ब्रहमामानडुकी Brahma manduki, ब्रह्म मंडुकी Brahma maṇḍukī"; Ayurvedic Pharmacopoeia of India, MANDUKAPARNI monograph, Hindi "Brahma Manduki, Brahmi".. How we source.

The evidence at a glance

12papers on this site for this drug, published 2001 to 2025, 11 with a DOI.

  • 3Systematic reviews and meta-analyses
  • 1Randomised controlled trials
  • 8Other clinical studies and reviews

A count is not a conclusion and a tier is a study design, not a verdict. Each paper is listed with what it measured on the page below. See the research index for how papers are tiered.

Names and identification

LanguageName
EnglishMandukparni

Ayurvedic pharmacology (Dravyaguna)

PropertyValueDescription
Rasa (Taste)TiktaPrimary taste
Guna (Quality)LaghuPhysical quality
Virya (Potency)SheetaHeating/Cooling effect
Vipaka (Post-digestive)MadhuraPost-digestive effect

Dosage forms and preparation

Dosage Forms: Svarasa (fresh juice), Churna (powder), Capsules, Tablets, Syrup, Ghrita (medicated ghee - Brahmi Ghrita), Medhya Rasayana formulations, Topical cream

Standard Dosage: 10-20 mL fresh juice daily; 3-6 g powder per day; 500-1000 mg standardized extract daily; 5-10 g Ghrita preparation daily

Optimal Timing: Morning on empty stomach, traditionally as a Medhya drug; Ghrita preparation with warm milk at bedtime; topical application twice daily, traditionally on wounds

Storage: Fresh plant refrigerated, process within 4 hours of harvest. Dried herb/extract below 25 deg C in airtight containers. Phytosome preparations in moisture-proof, nitrogen-flushed packaging. Ghrita in clean glass containers at room temperature. Protect all forms from light.

Marker Compounds: Asiaticoside, Madecassoside, Asiatic acid, Madecassic acid, Brahmoside, Brahminoside, Centellose, Isothankuniside

Synergistic Combinations

Published research

Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.

Systematic reviews and meta-analyses3

  1. Chan LKW, Lee KWA, Lee CH and others. 2024. Cosmeceuticals in photoaging: A reviewSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). PMID 39233460 · doi:10.1111/srt.13730
  2. Arribas-López E, Zand N, Ojo O and others. 2022. A Systematic Review of the Effect of Centella asiatica on Wound HealingInternational journal of environmental research and public health. PMID 35328954 · doi:10.3390/ijerph19063266
  3. Martinez-Zapata MJ, Vernooij RW, Simancas-Racines D and others. 2020. Phlebotonics for venous insufficiencyThe Cochrane database of systematic reviews. PMID 33141449 · doi:10.1002/14651858.CD003229.pub4

Randomised controlled trials1

  1. Cesarone MR, Belcaro G, Rulo A and others. 2001. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetryAngiology. PMID 11666123

Other clinical studies and reviews8

  1. Pavlov S, Prajapati SK, Yadav D and others. 2025. Advances in Bioactive Compounds from Plants and Their Applications in Alzheimer's DiseaseBiomolecules. PMID 41594549 · doi:10.3390/biom16010007
  2. Pattanaik SK, Anil PM, Jena S and others. 2025. Interlinking diabetes and Alzheimer's disease: A pathway through medicinal plant-based treatmentsJournal of ethnopharmacology. PMID 40484255 · doi:10.1016/j.jep.2025.120092
  3. Liang C, Ma Y, Ding M and others. 2025. Asiatic acid and its derivatives: Pharmacological insights and applicationsEuropean journal of medicinal chemistry. PMID 40015163 · doi:10.1016/j.ejmech.2025.117429
  4. Witkowska K, Paczkowska-Walendowska M, Garbiec E and others. 2024. Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical EfficacyPharmaceutics. PMID 39458583 · doi:10.3390/pharmaceutics16101252
  5. Bandopadhyay S, Mandal S, Ghorai M and others. 2023. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A reviewJournal of cellular and molecular medicine. PMID 36756687 · doi:10.1111/jcmm.17635
  6. Diniz LRL, Calado LL, Duarte ABS and others. 2023. Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic PotentialMetabolites. PMID 36837896 · doi:10.3390/metabo13020276
  7. Mandal S, Das T, Nandy S and others. 2023. Biotechnological and endophytic-mediated production of centellosides in Centella asiaticaApplied microbiology and biotechnology. PMID 36481800 · doi:10.1007/s00253-022-12316-z
  8. Taleb MH. 2023. Phenytoin's Pharmacological Interactions with Medicinal Herbs: A ReviewDie Pharmazie. PMID 37537774 · doi:10.1691/ph.2023.3546

Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.

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