Krishna Jeeraka
Krishna Jeeraka is a substance used in the Ayurvedic materia medica. SNEDDS and solid lipid nanoparticle formulations improve TQ bioavailability by 3-5 fold. Piperine co-administration increases TQ plasma levels by 50%. Fixed oil serves as natural lipid carrier enhancing TQ self-emulsification.
| Also known as | Krishna Jeeraka, KrishnaJeeraka |
|---|
Names and identification
| Language | Name |
|---|---|
| English | Krishna Jeeraka |
Ayurvedic pharmacology (Dravyaguna)
| Property | Value | Description |
|---|---|---|
| Rasa (Taste) | Katu | Primary taste |
| Guna (Quality) | Laghu, Ruksha | Physical quality |
| Virya (Potency) | Ushna | Heating/Cooling effect |
| Vipaka (Post-digestive) | Katu | Post-digestive effect |
What is it made of?
Mineral/Elemental Profile
- Primary component: Mineral-derived preparation
- Note: Composition varies by specific preparation method
Analytical Methods: XRD, ICP-OES, SEM-EDS
Dosage forms and preparation
Dosage Forms: Churna (powder), Capsule, Tablet, Taila (oil), Ark (distilled water), Essential oil
Standard Dosage: 1-3 g powder twice daily; 3-5 drops essential oil (diluted); 500 mg capsule twice daily; 5-10 mL Ark
Bioavailability: Thymoquinone (TQ) — primary bioactive — has moderate oral bioavailability (30-40%) limited by poor aqueous solubility and hepatic first-pass metabolism. SNEDDS and solid lipid nanoparticle formulations improve TQ bioavailability by 3-5 fold. Piperine co-administration increases TQ plasma levels by 50%. Fixed oil serves as natural lipid carrier enhancing TQ self-emulsification. Thymohydroquinone (reduced form) shows improved absorption.
Optimal Timing: After meals with honey (traditional); essential oil inhalation: anytime for respiratory benefit; before meals for appetite and digestive stimulation
Standardized Extract: Cold-pressed seed oil standardized to minimum 2% thymoquinone by HPLC; essential oil to minimum 35% thymoquinone and 25% p-cymene by GC-MS
Shelf Life: 18 months for seed powder; 24 months for cold-pressed oil (with tocopherol antioxidant); 36 months for soft gel capsules; 24 months for essential oil
Storage: Cold-pressed oil in amber glass bottles at 4-15°C (refrigeration extends potency). Seeds in airtight containers away from light. Thymoquinone degrades in heat and light — cold chain preferred for premium products.
Marker Compounds: Thymoquinone, Thymohydroquinone, Thymol, Carvacrol, p-Cymene, Alpha-pinene, Nigellone (dithymoquinone), Nigellidine, Nigellicine
Extraction Methods
- Cold pressing of seeds for fixed oil (Black seed oil)
- Steam distillation for essential oil
- Supercritical CO2 extraction for thymoquinone-enriched oil
- Hydroalcoholic extraction (70% ethanol) for non-oil fraction
- Enzyme-assisted aqueous extraction
Synergistic Combinations
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