Age Ayurveda Nighantu Ayurvedic practitioner? List or verify your practice

Dadima Twak

Punica granatum L. (fruit rind/pericarp)

Dadima Twak (Punica granatum L. (fruit rind/pericarp)) is a plant drug, from the Lythraceae (formerly Punicaceae) family. WHO monograph published for Pericarpium Granati (pomegranate rind); documented in Indian Pharmacopoeia; ESCOP and EMEA have referenced pomegranate preparations.

Key facts
Botanical namePunica granatum L. (fruit rind/pericarp)
FamilyLythraceae (formerly Punicaceae) · other entries in this family
OrderMyrtales
Also known asDadima Twak, DadimaTwak, Punica granatum L. (fruit rind/pericarp)
Pharmacopoeia statusWHO monograph published for Pericarpium Granati (pomegranate rind); documented in Indian Pharmacopoeia; ESCOP and EMEA have referenced pomegranate preparations
Taxon identifiersGBIF 5420901 · Wikidata Q52558783 · NCBI Taxonomy 22663

The evidence at a glance

12papers on this site for this drug, published 2017 to 2024, every one with a DOI.

  • 2Systematic reviews and meta-analyses
  • 1Randomised controlled trials
  • 9Other clinical studies and reviews

A count is not a conclusion and a tier is a study design, not a verdict. Each paper is listed with what it measured on the page below. See the research index for how papers are tiered.

Names and identification

LanguageName
EnglishDadima Twak
Latin/BotanicalPunica granatum L. (fruit rind/pericarp)

Key Phytochemical Constituents

How does it work?

  • Punicalagin and ellagic acid are hydrolyzed by gut microbiota to urolithins (A, B, C, D), which exert anti-inflammatory effects by inhibiting NF-kB and MAPK signaling pathways
  • Pelletierine and isopelletierine alkaloids have been reported to have anthelmintic activity, paralyzing tapeworm musculature through nicotinic receptor agonism.
  • Gallic acid and catechins provide antimicrobial activity through disruption of bacterial cell membrane integrity and inhibition of biofilm formation by chelating metal ions essential for bacterial adhesion

Which traditional uses are supported by research?

These summaries come from the source notes, which do not name the studies behind them.

  • Dadima Twak is traditionally used in Ayurveda for Krimi (intestinal parasites), including tapeworms. Pelletierine alkaloids have been identified in the rind.
  • Traditionally used for Atisara (diarrhea) and Pravahika (dysentery). Its tannins have been reported to have an astringent effect on the intestinal mucosa.
  • Pomegranate rind decoction is traditionally used for Mukha Roga (oral diseases). Antimicrobial activity against oral pathogens and gastrointestinal bacteria has been reported.

What do recent studies show?

Only studies that could be traced to a published paper are listed here. An absence here means we could not identify the source, not that no work exists.

Recent safety updates

  • WHO monograph for Pericarpium Granati confirmed no genotoxic effects; Cosmetic Ingredient Review Expert Panel (2019) deemed pomegranate-derived ingredients safe for use
  • Pelletierine alkaloids in bark/rind can cause nausea, vomiting, and diarrhea at high doses; traditional preparation methods (decoction) help control alkaloid concentration
  • Pomegranate juice/extract may interact with CYP3A4-metabolized drugs (statins, calcium channel blockers) similarly to grapefruit; monitor patients on warfarin for enhanced anticoagulant effects

What is it made of?

Key Active Markers

  • Punicalagin
  • Punicalin
  • Catechin
  • Epicatechin
  • Corilagin
  • Ellagic acid
  • Gallic acid
  • Pelletierine
  • Isopelletierine
  • Tannic acid

Dosage forms and preparation

Dosage Forms: Churna (powder), Kashayam (decoction), Tablet, Capsule, Kwath (decoction concentrate)

Standard Dosage: 3-6g powder twice daily; 50-100ml decoction twice daily; 500mg tablet/capsule twice daily

Optimal Timing: Before meals with warm water; for anthelmintic use, on an empty stomach in the morning

Storage: Store in airtight containers below 25 deg C, protected from light and moisture. Tannins oxidize on prolonged light exposure leading to darkening and potency loss.

Marker Compounds: Punicalagin (alpha and beta), Ellagic acid, Punicalin, Gallic acid, Granatin B

Synergistic Combinations

  • With Kutaja (Holarrhena), traditionally paired for Atisara (diarrhea)
  • With Musta (Cyperus rotundus), traditionally paired as a GI astringent
  • With Haritaki, traditionally paired for Krimi (intestinal parasites)
  • With Sunthi (ginger), traditionally paired to offset its astringency

Published research

Literature indexed in PubMed that concerns this subject, grouped by study type. A paper appearing here is a record of what has been published, not evidence that the subject works, and laboratory or animal results do not transfer to people. Study titles link to PubMed so you can read the source rather than take our word.

Systematic reviews and meta-analyses2

  1. Morgado A, Tsampoukas G, Sokolakis I and others. 2024. Do "testosterone boosters" really increase serum total testosterone? A systematic reviewInternational journal of impotence research. PMID 37697053 · doi:10.1038/s41443-023-00763-9
  2. Molani-Gol R, Foroumandi E, Alizadeh M and others. 2023. Pomegranate and Cognitive Performance: A Systematic ReviewCurrent pharmaceutical design. PMID 37005403 · doi:10.2174/1381612829666230330163645

Randomised controlled trials1

  1. Razani Z, Dastani M, Kazerani HR. 2017. Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart DiseasePhytotherapy research : PTR. PMID 28913846 · doi:10.1002/ptr.5901

Other clinical studies and reviews9

  1. Dogara AM, Hama HA, Ozdemir D. 2024. Update on the Potential of Punica granatum L. Traditional Uses and Pharmacological Uses: A ReviewAdvances in pharmacological and pharmaceutical sciences. PMID 39649727 · doi:10.1155/adpp/6523809
  2. Azmat F, Safdar M, Ahmad H and others. 2024. Phytochemical profile, nutritional composition of pomegranate peel and peel extract as a potential source of nutraceutical: A comprehensive reviewFood science & nutrition. PMID 38370077 · doi:10.1002/fsn3.3777
  3. Mohan M, C A M, D P and others. 2024. Review of Pharmacological and Medicinal Uses of Punica granatumCureus. PMID 39552993 · doi:10.7759/cureus.71510
  4. Tornese R, Montefusco A, Placì R and others. 2024. Antiangiogenic Potential of Pomegranate ExtractsPlants (Basel, Switzerland). PMID 39683144 · doi:10.3390/plants13233350
  5. Zhao B, Zhang C, Guo T and others. 2024. Punica granatum L. polysaccharides: A review on extraction, structural characteristics and bioactivitiesCarbohydrate research. PMID 39178695 · doi:10.1016/j.carres.2024.109246
  6. Dimitrijevic J, Tomovic M, Bradic J and others. 2024. Punica granatum L. (Pomegranate) Extracts and Their Effects on Healthy and Diseased SkinPharmaceutics. PMID 38675119 · doi:10.3390/pharmaceutics16040458
  7. Cordiano R, Gammeri L, Di Salvo E and others. 2024. Pomegranate (Punica granatum L.) Extract Effects on InflammagingMolecules (Basel, Switzerland). PMID 39275022 · doi:10.3390/molecules29174174
  8. Aleksandrova S, Alexova R, Dragomanova S and others. 2023. Preventive and Therapeutic Effects of Punica granatum L. Polyphenols in Neurological ConditionsInternational journal of molecular sciences. PMID 36768185 · doi:10.3390/ijms24031856
  9. Alexova R, Alexandrova S, Dragomanova S and others. 2023. Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum LMolecules (Basel, Switzerland). PMID 37175181 · doi:10.3390/molecules28093772

Reference lists that include it

Catechin, Ellagic acid, Gallic acid

Reviewed by Dr. Awadesh Pratap Singh, BAMS, on 11 October 2026. What that review covered.

Consult a qualified vaidya before acting on anything here. Ayurvedic practice is prescribed to a person, not to a condition: the same dravya is given, withheld or substituted depending on your constitution, your agni, the season and what else you are already taking. A page cannot know any of that. Self-prescribing from a reference is how the wrong preparation, the wrong dose or the wrong anupana gets used.

Educational reference only. Nothing on this page is medical advice, a diagnosis, or a recommendation to take anything. Traditional uses and research findings are reported as published, not as claims about what any product does. If you take prescribed medication, raise any interaction with the prescriber rather than acting on a page. See our editorial standards.