# Jyotishmati > Jyotishmati (Celastrus paniculatus) is a plant used in Ayurveda. Total PubMed publications found: 75 Authors: Kulkarni Yogesh A, Agarwal Sneha, Garud Mayuresh S Journal: Journal of Ayurveda and integrative medicine (2015) PMID: 26166997 > Jyotishmati, scientifically known as Celastrus paniculatus Wild (Celastraceae) is one of the most important medicinal plants in Ayurveda. ## Key facts - **Botanical name:** Celastrus paniculatus ## Names and identification | Language | Name | |----------|------| | English | Jyotishmati | ## Modern Research (Meta-Analysis) **Total PubMed publications found:** 75 ### Key Research Papers #### 1. Effect of Jyotishmati (Celastrus paniculatus) seeds in animal models of pain and inflammation. **Authors:** Kulkarni Yogesh A, Agarwal Sneha, Garud Mayuresh S **Journal:** Journal of Ayurveda and integrative medicine (2015) **PMID:** 26166997 > Jyotishmati, scientifically known as Celastrus paniculatus Wild (Celastraceae) is one of the most important medicinal plants in Ayurveda. The plant has shown significant pharmacological activities like anti-arthritic, wound healing, [hypolipidemic](/glossary/pharmacology/#hypolipidemic), and [antioxidant](/reference/antioxidant/).... **Keywords:** Acetic acid, [analgesic](/reference/analgesic/), anti-inflammatory, carrageenan, hot plate, tail immersion #### 2. Phytochemistry and pharmacology of **Authors:** Aleem Mohd **Journal:** Journal of complementary & integrative medicine (2023) **PMID:** 34529902 > OBJECTIVES: METHODS: All available information concerning RESULTS: CONCLUSIONS: Several ... **Keywords:** Celastrus paniculatus, malkangni, [neuroprotective](/reference/neuroprotective/), [nootropic](/glossary/pharmacology/#nootropic), traditional uses, β-dihydroagarofuranoids sesquiterpenes #### 3. Application of Green Technologies in Design-Based Extraction of **Authors:** Arya Ashwani, Kaushik Deepak, Almeer Rafa et al. **Journal:** Frontiers in nutrition (2022) **PMID:** 35662919 > The ... **Keywords:** Box-Behnken design, Celastrus paniculatus, anti-cholinesterase, antioxidant, gas chromatography, green approach, response surface methodology, scanning electron microscopy #### 4. Neuroprotective potential of **Authors:** Sankaramourthy Divya, Sankaranarayanan Lakshmi, Subramanian Kavimani et al. **Journal:** Journal of complementary & integrative medicine (2023) **PMID:** 35005853 > The most common human neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) etc. have been recognized to result from a complex interplay between genetic predisposition and defective cellular dynamics such as inappropriate accumulation of unfolded [proteins](/glossary/compounds-o-q/#proteins), oxygen free radicals and mitochondrial dysfunction. The treatment strategies available today for these neurodegenerative ailments are only palliative and are incapable of restraining the progression of the disease. Hence, there is an immense requirement for identification of drug candidates with the ability to alleviate neuronal damage along with controlling progression of the disease. From time immemorial mankind has been relying on plants for treating varied types of dreadful dise... **Keywords:** Celastrus paniculatus, antioxidants, cognitive dysfunction, neurobehavioral, neuroprotective #### 5. Phytochemical and analytical evaluation of Jyotishmati (Celastrus paniculatus Willd.) leaf extracts. **Authors:** Debnath Monojit, Biswas Moulisha, Shukla Vinay J et al. **Journal:** Ayu (2014) **PMID:** 25364201 > Jyotishmati (Celastrus paniculatus Willd.) is a woody climber belongs to the family Celastraceae; a well known herbal nootropic, distributed through the tropical and subtropical regions of India. Its leaves are used in eye disease and headache. Very low qualitative and quantitative information about leaves have been documented to establish its quality and purity.... **Keywords:** Celastrus paniculatus, Jyotishmati leaf, high-performance thin layer chromatography, phytochemistry #### 6. An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd. **Authors:** Nagpal Kajal, Garg Madhukar, Arora Deepshi et al. **Journal:** Phytotherapy research : PTR (2022) **PMID:** 35199395 > Celastrus paniculatus is a traditional herb belonging to the family Celastraceae and is widely used for a number of medicinal activities in the Indian Unani and Ayurvedic systems. In this study, the extensive literature search was carried out on phytochemistry, ethnobotanical uses and pharmacological activities of C. paniculatus (Willd.) in various scientific databases as well as patents. Research on phytochemical investigation has shown the presence of [monoterpenes](/glossary/compounds-l-o/#monoterpenes) ([linalool](/glossary/compounds-l-o/#linalool), α-terpinyl acetate, [nerol](/glossary/compounds-l-o/#nerol) acetate), sesqueterpene esters (such as malkanguniol, malkangunin, valerenal, globulol, [viridiflorol](/glossary/compounds-t-z/#viridiflorol), cubenol and agarofuran derivatives), diterpenoids (such as phytone, isophytol), [triterpenoids](/glossary/compounds-t-z/#triterpenoids) (such as [lupeol](/reference/lupeol/), pristimerin, paniculatadiol, zeylasteral, zeylasterone, β-amyrin, [squalene](/glossary/compounds-q-t/#squalene)), al... **Keywords:** Celastraceae, Celastrus paniculatus, Jyotishmati, Malkangni, pharmacological activities, phytochemistry #### 7. Neuroprotective Effect of **Authors:** Ralta Arti, Prakash Ajay, Kumar M Praveen et al. **Journal:** Basic and clinical neuroscience (2023) **PMID:** 37346867 > Cognitive deficit is one of the common comorbidity accompanying epilepsy. The present study evaluated the effect of ... **Keywords:** C. paniculatus, Hippocampus, Kindling, Oxidative stress, Pentylenetetrazole #### 8. Neuroprotective capacity of Celastrus paniculatus on rotenone-induced parkinsonism in zebrafish model. **Authors:** Manoharan Nivedita, Jayamurali Dheepthi, Sridhar Anitha et al. **Journal:** Molecular biology reports (2025) **PMID:** 40024951 > Parkinson's disease, a neurodegenerative disorder, affects millions globally, with age, genetics, and environmental conditions increasing risk. Global burden could reach 12 million by 2050. To observe the effect of Celastrus paniculatus in rotenone-induced Parkinsonism in zebrafish model.... **Keywords:** Celastrus paniculatus, Parkinson’s disease, Rotenone ## What is it made of? ### Key Active Markers - Derived from constituent herbs (see individual herb profiles) - Standardized on primary bioactive markers **Analytical Methods:** HPLC fingerprinting, TLC (identity), LC-MS/MS (marker quantification) ## Dosage forms and preparation **Dosage Forms:** Taila (seed oil), Capsule, Tablet, Churna (seed powder), Matra Basti (oil enema), Nasya (nasal oil) **Standard Dosage:** 5-15 drops seed oil twice daily; 500mg-1g seed powder; 250-500mg extract; 2-4 drops Nasya oil per nostril **Bioavailability:** Celastrus paniculatus seed oil contains sesquiterpenes, polyester [alkaloids](/glossary/compounds-1-a/#alkaloids) (celapanin, celastrine), and fatty acids. Seed oil fatty acids are well absorbed. Sesquiterpene and alkaloid components show good lipophilic absorption. Nasya (nasal) administration provides direct CNS access for nootropic effects, bypassing hepatic first-pass metabolism. Oil form has inherently good bioavailability for lipophilic actives. **Optimal Timing:** Morning on empty stomach with warm water/milk for cognitive effects; Nasya in early morning; gradual dose escalation over 2-3 weeks **Standardized Extract:** Cold-pressed seed oil (primary product); oil standardized to fatty acid profile and total alkaloid content (>0.5%); CO2 extract for enriched alkaloid fraction **Shelf Life:** 1 year (cold-pressed oil without antioxidants); 2 years (oil with antioxidant, sealed); 2 years (capsule/soft gel); 2 years (seed powder) **Storage:** Oil: amber glass bottles, nitrogen-flushed, below 25°C, protected from light. Seed powder: airtight containers, cool and dry. Refrigeration extends oil shelf life. **Marker Compounds:** Celapanin, Celastrine, Malkanginnol, Pristimerin, Zeylasterone, Oleic acid, Linoleic acid, Palmitic acid ### Extraction Methods - Cold pressing of seeds (oil extraction, 40-50% oil content) - Supercritical CO2 extraction for alkaloid-enriched oil - Hydroalcoholic extraction of seed cake (70:30) - Traditional oil processing (Murchhita Taila - oil processing with prescribed herbs) ### Synergistic Combinations - With [Brahmi](/herb/brahmi/) for cognitive enhancement and memory - With [Shankhpushpi](/herb/shankhpushpi/) for mental clarity - With [Jatamansi](/herb/jatamansi/) for [anxiolytic](/reference/anxiolytic/) and nootropic synergy - With [Vacha](/herb/vacha/) for speech and memory disorders - With [Ashwagandha](/herb/ashwagandha/) for neuroprotection --- Canonical version of this page: https://nighantu.ageayurveda.com/herb/jyotishmati/ ## Sources - Amidha Ayurveda Herb Database (700+ herbs, CC-BY-4.0) - PubMed / NCBI (75 publications) - AgeAyurveda Product Catalog - Ayurvedic Pharmacopoeia of India Published by Age Ayurveda in the Nighantu. Educational reference only, not medical advice. Incorporates material from the Amidha Ayurveda Herb Database under CC BY 4.0.