# Kutajarishta

> Kutajarishta is a classical Ayurvedic fermented arishta or asava. Listed in the Ayurvedic Formulary of India (AFI) Part I. Charaka Samhita (Chikitsa Sthana) - Kutaja referenced for Pravahika (dysentery with mucus) and Atisara (diarrhea).

## Key facts

- **Pharmacopoeia status:** Listed in the Ayurvedic Formulary of India (AFI) Part I. Referenced in the Ayurvedic Pharmacopoeia of India (API). Kutaja bark monograph available in API Part I. One of the most established anti-diarrheal formulations in classical Ayurveda with widespread clinical use.

## Names and identification

| Language | Name |
|----------|------|
| English | Kutajarishta |

## Where is it described in the classical texts?

Charaka Samhita (Chikitsa Sthana) - Kutaja referenced for Pravahika (dysentery with mucus) and Atisara (diarrhea). Sushruta Samhita describes Tikta-kashaya rasa and Sheeta virya properties. Arishta preparation detailed in Sharangdhara Samhita and Bhaishajya Ratnavali (Atisara Rogadhikara).

## How does it work?

- Calcium channel blockade: Kutaja (Holarrhena antidysenterica) extract blocks calcium channels in intestinal smooth muscle, reducing cramping and motility.
- [Potassium](/glossary/compounds-o-q/#potassium) channel and nitric oxide pathway modulation: Antidiarrheal effect mediated through potassium channels and NO pathway (not alpha-2 adrenergic receptors).
- Bacterial adenylate cyclase inhibition: Conessine (major steroidal alkaloid) inhibits bacterial adenylate cyclase, directly reducing toxin-mediated secretory diarrhea.
- Antisecretory action: Reduces excessive intestinal fluid secretion by modulating electrolyte transport across intestinal epithelium.
- [Antimicrobial](/reference/antimicrobial/) activity: [Alkaloids](/glossary/compounds-1-a/#alkaloids) (conessine, kurchine) exhibit potent activity against enteric pathogens including E. histolytica, Shigella, and E. coli.

## Which traditional uses are supported by research?

- Amoebic dysentery (validated by clinical trial showing 60% reduction in stool frequency against E. histolytica)
- Non-infectious diarrhea (validated by RCT showing 58% stool frequency reduction within 3 days, outperforming loperamide)
- Secretory diarrhea (validated by conessine-mediated bacterial adenylate cyclase inhibition)
- IBS with diarrhea (supported by antimotility and antisecretory mechanism studies)

## What do recent clinical trials show?



*4 further claims previously listed here could not be traced to a published paper and have been removed. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.*

## Recent safety updates

- Generally well-tolerated at recommended doses (15-30 mL twice daily after meals). Contains self-generated alcohol from fermentation; caution advised for those with liver conditions or alcohol sensitivity.
- Long-term clinical trials in humans remain limited; most evidence comes from acute diarrhea contexts. Avoid in patients with constipation or intestinal obstruction.
- Not recommended during pregnancy without medical supervision. Holarrhena antidysenterica alkaloids may interact with cardiac medications; consult physician if on concurrent drug therapy.

## What is it made of?

### Mineral/Elemental Profile

- **Primary component:** Mineral-derived preparation
- **Note:** Composition varies by specific preparation method

**Analytical Methods:** XRD, ICP-OES, SEM-EDS

## Dosage forms and preparation

**Dosage Forms:** Arishta/Asava (fermented liquid), Syrup (modern adaptation)

**Standard Dosage:** 15-30ml with equal water after meals

**Bioavailability:** Self-generated alcohol enhances extraction and absorption of both water-soluble and fat-soluble compounds; fermentation produces bioactive metabolites not present in raw herbs

**Optimal Timing:** After meals, twice daily

**Shelf Life:** Indefinite per classical texts; commercially labeled 5-10 years. Improves with age.

**Storage:** Room temperature, tightly sealed, away from direct sunlight. Do not refrigerate.

**Marker Compounds:** Conessine, Kurchine

**Quality Parameters:** Alcohol content 5-12% v/v, pH 3.0-4.5, specific gravity 1.01-1.08, total solids 15-25%, marker: Conessine, Kurchine

**Vehicle (Anupana):** Equal quantity of water after meals

### Synergistic Combinations

- Key herbs: Kutaja (Holarrhena antidysenterica), [Dhataki](/herb/dhataki/); fermentation creates unique metabolite profile with enhanced therapeutic activity

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Canonical version of this page: https://nighantu.ageayurveda.com/formulation/kutajarishta/

## Sources

- Amidha Ayurveda Herb Database (700+ herbs, CC-BY-4.0)
- Web research (clinical trials, WHO monographs, safety databases)
- Ayurvedic Pharmacopoeia of India
- Classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Bhavaprakasha Nighantu)

Published by Age Ayurveda in the Nighantu. Educational reference only, not medical advice.
Incorporates material from the Amidha Ayurveda Herb Database under CC BY 4.0.