# Kaishore Guggul

> Kaishore Guggul is a classical Ayurvedic guggulu, a resin-based preparation. Listed in Ayurvedic Formulary of India (AFI) Part I; monographed in Ayurvedic Pharmacopoeia of India (API); recognized by CCRAS (Central Council for Research in Ayurvedic Sciences).

## Key facts

- **Pharmacopoeia status:** Listed in Ayurvedic Formulary of India (AFI) Part I; monographed in Ayurvedic Pharmacopoeia of India (API); recognized by CCRAS (Central Council for Research in Ayurvedic Sciences)

## Names and identification

| Language | Name |
|----------|------|
| English | Kaishore Guggul |

## Where is it described in the classical texts?

Sharangdhara Samhita (Madhyama Khanda, Chapter 7); also referenced in Bhaishajya Ratnavali (Vatarakta Chikitsa)

## How does it work?

- Uric acid reduction: Guggulsterones promote renal excretion of uric acid by modulating renal tubular transporters (URAT1, GLUT9), reducing hyperuricemia
- Anti-inflammatory cascade: [Guduchi](/herb/guduchi/) (Tinospora cordifolia) contains [berberine](/glossary/compounds-a-c/#berberine) and [tinosporaside](/glossary/compounds-t-z/#tinosporaside) that inhibit NF-kB signaling and suppress TNF-alpha, IL-1beta, and IL-6 production
- [Antioxidant](/reference/antioxidant/) defense: [Triphala](/herb/triphala/) and [Guduchi](/herb/guduchi/) [polyphenols](/glossary/compounds-o-q/#polyphenols) scavenge reactive oxygen species, protecting joint cartilage from oxidative degradation
- Blood purification (Rakta Shodhana): Combined action of [Guduchi](/herb/guduchi/) and [Triphala](/herb/triphala/) detoxify blood by enhancing hepatic conjugation pathways and promoting elimination of metabolic waste
- Bioavailability enhancement: [Trikatu](/herb/trikatu/) (especially [piperine](/reference/piperine/) from Maricha and [Pippali](/herb/pippali/)) enhances intestinal absorption and inhibits P-glycoprotein efflux, increasing systemic availability of active compounds

## Which traditional uses are supported by research?

- Gout (Vatarakta) management validated through clinical case series showing significant reduction in uric acid levels and joint inflammation
- Blood purification and skin disease management supported by antioxidant and anti-inflammatory activity confirmed in pharmacological studies
- Anti-inflammatory and [analgesic](/reference/analgesic/) activity validated through inhibition of carrageenan-induced paw edema in animal models
- Detoxification (Ama Pachana) supported by enhanced hepatic function and metabolic waste elimination in clinical observations

## What do recent clinical trials show?



*3 further claims previously listed here could not be traced to a published paper and have been removed. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.*

## Recent safety updates

- Generally considered safe under practitioner supervision; possible side effects include mild digestive discomfort and gastric upset; may lower blood sugar and blood pressure, requiring monitoring in diabetic and hypotensive patients
- Contraindicated during pregnancy; not recommended for children below 5 years; patients with bleeding disorders should use cautiously as guggul may slow blood clotting; avoid concurrent use with anticoagulant medications

## What is it made of?

### Mineral/Elemental Profile

- **Primary component:** Mineral-derived preparation
- **Note:** Composition varies by specific preparation method

**Analytical Methods:** XRD, ICP-OES, SEM-EDS

## Dosage forms and preparation

**Dosage Forms:** [Guggulu](/formulation/guggulu/) (resinous pill/tablet), Modern compressed tablet, Capsule (modern)

**Standard Dosage:** 250-500 mg twice or thrice daily with warm water, as per AFI Part I

**Bioavailability:** [Guggulu](/formulation/guggulu/) resin acts as yogavahi — enhances delivery of anti-inflammatory compounds to joints and blood. Piperine from [Trikatu](/herb/trikatu/) significantly enhances absorption of [berberine](/glossary/compounds-a-c/#berberine) and guggulsterones. Multi-herb synergy provides broad anti-inflammatory action with high tissue bioavailability.

**Optimal Timing:** After meals, twice or thrice daily, for Vatarakta (gout), Kushtha (skin diseases), and inflammatory conditions

**Shelf Life:** 3 years from date of manufacture as per ASU guidelines for Guggulu preparations

**Storage:** Store in airtight containers in a cool, dry place. Temperature not exceeding 30°C.

**Marker Compounds:** Z-Guggulsterone, E-Guggulsterone, [Berberine](/glossary/compounds-a-c/#berberine) (from [Guduchi](/herb/guduchi/)), Piperine, Gallic acid, [Embelin](/glossary/compounds-d-g/#embelin) (from [Vidanga](/herb/vidanga/))

**Quality Parameters:** Weight variation (±5%), hardness, friability (<1%), disintegration time (<45 min), moisture (<6%), Z/E-guggulsterone content by HPLC, berberine from [Guduchi](/herb/guduchi/), piperine, gallic acid, HPTLC fingerprint, microbial limits, heavy metals

**Vehicle (Anupana):** Warm water or Guduchi kwath

### Synergistic Combinations

- [Guggulutiktakam Ghritam](/formulation/guggulutiktakam-ghritam/)
- Mahamanjisthadi Kwath
- [Gandhaka](/glossary/concepts-a-m/#gandhaka) [Rasayana](/reference/rasayana/)
- [Arogyavardhini Vati](/formulation/arogyavardhini-vati/)

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Canonical version of this page: https://nighantu.ageayurveda.com/formulation/kaishore-guggul/

## Sources

- Amidha Ayurveda Herb Database (700+ herbs, CC-BY-4.0)
- Web research (clinical trials, WHO monographs, safety databases)
- Ayurvedic Pharmacopoeia of India
- Classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Bhavaprakasha Nighantu)

Published by Age Ayurveda in the Nighantu. Educational reference only, not medical advice.
Incorporates material from the Amidha Ayurveda Herb Database under CC BY 4.0.