# Guloochyadi Kashayam

> Guloochyadi Kashayam is a classical Ayurvedic kashaya, a water decoction. Listed in the Ayurvedic Formulary of India (AFI). Sharangdhara Samhita Madhyamakhanda 2/8; Astanga Hridayam. Earliest explicit mention in Sahasrayogam (circa 15th century CE southern compendium) under Jwara Chikitsa (fever treatment).

## Key facts

- **Pharmacopoeia status:** Listed in the Ayurvedic Formulary of India (AFI). Referenced in Sharangdhara Samhita and Sahasrayogam. Recognized by the Pharmacopoeia Commission for Indian Medicine & Homoeopathy (PCIM&H).

## Names and identification

| Language | Name |
|----------|------|
| English | [Guloochyadi Kashayam](/formulation/guloochyadi-kashayam/) |

## Where is it described in the classical texts?

Sharangdhara Samhita Madhyamakhanda 2/8; Astanga Hridayam. Earliest explicit mention in Sahasrayogam (circa 15th century CE southern compendium) under Jwara Chikitsa (fever treatment).

## How does it work?

- [Immunomodulatory](/reference/immunomodulatory/) action through NK cell activation and enhanced non-specific immunity ([Guduchi](/herb/guduchi/), [Nimba](/herb/nimba/))
- Anti-inflammatory activity via suppression of pro-inflammatory cytokines and reduction of CRP levels
- [Antipyretic](/reference/antipyretic/) action through multiple pathways including prostaglandin synthesis inhibition
- [Antioxidant](/reference/antioxidant/), antibacterial, antiviral, and antimalarial activities from the synergistic herb combination

## Which traditional uses are supported by research?

- Fever of various etiologies - validated by immunomodulatory and antipyretic studies
- Burning sensation (Daha) - supported by cooling properties of Raktachandana and [Padmaka](/herb/padmaka/)
- Loss of appetite and nausea during fever - corroborated by digestive and [antiemetic](/glossary/pharmacology/#antiemetic) properties
- Infections with inflammatory component - supported by anti-inflammatory CRP reduction data

## What do recent clinical trials show?



*3 further claims previously listed here could not be traced to a published paper and have been removed. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.*

## Recent safety updates

- Generally well tolerated. No significant adverse effects reported in clinical trials. May cause mild gastrointestinal discomfort in sensitive individuals.
- [Guduchi](/herb/guduchi/) may lower blood sugar; diabetic patients on hypoglycemics should use with caution and monitor blood [glucose](/glossary/compounds-d-g/#glucose) levels. [Neem](/herb/neem/) ([Nimba](/herb/nimba/)) should be used cautiously in pregnancy.

## What is it made of?

### Key Active Markers

- Derived from constituent herbs (see individual herb profiles)
- Standardized on primary bioactive markers

**Analytical Methods:** HPLC fingerprinting, TLC (identity), LC-MS/MS (marker quantification)

## Dosage forms and preparation

**Dosage Forms:** Kashayam (decoction), Kashayam tablet (modern), Concentrated liquid (modern)

**Standard Dosage:** 15-30 mL or 2 tablets twice daily before meals, as per Sahasrayogam

**Bioavailability:** Hot decoction provides rapid absorption of [Guduchi](/herb/guduchi/) [alkaloids](/glossary/compounds-1-a/#alkaloids) and [glycosides](/glossary/compounds-g-l/#glycosides). [Berberine](/glossary/compounds-a-c/#berberine) has moderate oral bioavailability (~5%) enhanced in hot aqueous medium. [Tinosporaside](/glossary/compounds-t-z/#tinosporaside) and [polysaccharides](/glossary/compounds-o-q/#polysaccharides) are well-absorbed from decoction.

**Optimal Timing:** Before meals, morning and evening, especially for Jwara (fever) and immunomodulation

**Shelf Life:** Same day (fresh), 6 months (preserved), 3 years (tablet)

**Storage:** Fresh: use same day. Concentrates: amber glass at room temperature. Tablets: airtight containers at room temperature.

**Marker Compounds:** [Berberine](/glossary/compounds-a-c/#berberine), Tinosporaside, [Columbin](/glossary/compounds-c-d/#columbin), [Palmatine](/glossary/compounds-o-q/#palmatine), [Magnoflorine](/glossary/compounds-l-o/#magnoflorine), [Arabinogalactan](/glossary/compounds-1-a/#arabinogalactan) (polysaccharide)

**Quality Parameters:** pH, specific gravity, total solids, berberine content by HPLC, tinosporaside content, total alkaloids, HPTLC fingerprint, microbial limits, heavy metals

**Vehicle (Anupana):** Warm water (tablets); as is (liquid kashayam)

### Synergistic Combinations

- [Amritarishta](/formulation/amritarishta/)
- [Guduchi](/herb/guduchi/) Satva
- Sudarshana Churna
- Panchanimba Churna

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Canonical version of this page: https://nighantu.ageayurveda.com/formulation/guloochyadi-kashayam/

## Sources

- Amidha Ayurveda Herb Database (700+ herbs, CC-BY-4.0)
- Web research (clinical trials, WHO monographs, safety databases)
- Ayurvedic Pharmacopoeia of India
- Classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Bhavaprakasha Nighantu)

Published by Age Ayurveda in the Nighantu. Educational reference only, not medical advice.
Incorporates material from the Amidha Ayurveda Herb Database under CC BY 4.0.