# Dadimadi Ghrita

> Dadimadi Ghrita is a classical Ayurvedic ghrita, a medicated ghee. Listed in Ayurvedic Pharmacopoeia of India (API); standardized following API norms; formulations procured from GMP-certified Ayurvedic pharmaceutical industries for clinical research.

## Key facts

- **Pharmacopoeia status:** Listed in Ayurvedic Pharmacopoeia of India (API); standardized following API norms; formulations procured from GMP-certified Ayurvedic pharmaceutical industries for clinical research

## Names and identification

| Language | Name |
|----------|------|
| English | Dadimadi [Ghrita](/herb/ghrita/)|Dadimadi Ghrita |

## Where is it described in the classical texts?

Ashtanga Hridaya (Brihat Trayi compendia, 1st century CE); Charaka Samhita; Sushruta Samhita; Kashyapa Samhita (12th century) for throat conditions

## How does it work?

- [Dadima](/herb/dadima/) (pomegranate) provides iron, folic acid, and [polyphenols](/glossary/compounds-o-q/#polyphenols) that directly support hemoglobin synthesis and erythropoiesis
- Chitraka ([plumbagin](/glossary/compounds-o-q/#plumbagin)) stimulates Agni (digestive fire), enhancing iron absorption from dietary sources
- [Pippali](/herb/pippali/) and Shunthi improve bioavailability of nutrients through enhanced hepatic and intestinal enzyme activity
- Ghee base provides fat-soluble vitamin delivery and enhances absorption of mineral supplements
- Deepana (appetizer) and Pachana (digestive) properties improve overall nutritional status and tissue nourishment

## Which traditional uses are supported by research?

- Pandu (anemia): multicenter clinical trial validates significant improvement in serum iron and hemoglobin with 103 patients
- Garbhini Pandu (anemia in pregnancy): validated safe and effective in 35 pregnant subjects without fetal harm
- Deepana (digestive stimulation): confirmed improvement in Agni (digestive power) and nutritional status
- Arsha (hemorrhoids): traditional indication supported by anti-inflammatory and digestive properties of ingredients

## What do recent clinical trials show?



*3 further claims previously listed here could not be traced to a published paper and have been removed. Classical formulations are researched largely in journals that PubMed does not index, so an absence here reflects the reach of the index rather than the state of the evidence.*

## Recent safety updates

- Multicenter clinical study confirms safety in 103 patients over 12-week period; all safety parameters within normal range; no adverse drug reactions or events reported
- Safe for use during pregnancy for anemia management at 10ml daily for 30 days with no fetal or maternal side effects
- Standardized as per Ayurvedic Pharmacopoeia of India; procured from GMP-certified pharmaceutical industries

## What is it made of?

### Mineral/Elemental Profile

- **Primary component:** Mineral-derived preparation
- **Note:** Composition varies by specific preparation method

**Analytical Methods:** XRD, ICP-OES, SEM-EDS

## Dosage forms and preparation

**Dosage Forms:** [Ghrita](/herb/ghrita/) (medicated ghee), Soft gelatin capsules (modern)

**Standard Dosage:** 6-12 g twice daily, as per AFI Part I

**Bioavailability:** Ghee matrix enhances absorption of pomegranate polyphenols ([punicalagin](/glossary/compounds-o-q/#punicalagin), ellagic acid). Lipid base protects [ellagitannins](/glossary/compounds-d-g/#ellagitannins) from gastric degradation, enabling colonic conversion to urolithins (bioactive metabolites).

**Optimal Timing:** Before meals or as directed, for Atisara (diarrhea) and Grahani conditions

**Shelf Life:** 2 years from date of manufacture as per ASU guidelines for [Ghrita](/herb/ghrita/) preparations

**Storage:** Store in airtight glass or tin containers in a cool, dry place. Protect from moisture and light. Temperature not exceeding 25°C.

**Marker Compounds:** Punicalagin, [Punicalin](/glossary/compounds-o-q/#punicalin), Ellagic acid, Gallic acid, Punicic acid

**Quality Parameters:** Acid value (<6), peroxide value (<10), saponification value, refractive index, moisture (<0.5%), rancidity test negative, punicalagin content from [Dadima](/herb/dadima/) by HPLC, total polyphenols, total [tannins](/reference/tannins/), microbial limits, heavy metals

**Vehicle (Anupana):** Warm water or buttermilk

### Synergistic Combinations

- [Bilwadi Leha](/formulation/bilwadi-leha/)
- [Kutajarishta](/formulation/kutajarishta/)
- [Gangadhara Churna](/formulation/gangadhara-churna/)
- [Changeri](/herb/changeri/) Ghrita

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Canonical version of this page: https://nighantu.ageayurveda.com/formulation/dadimadi-ghrita/

## Sources

- Amidha Ayurveda Herb Database (700+ herbs, CC-BY-4.0)
- Web research (clinical trials, WHO monographs, safety databases)
- Ayurvedic Pharmacopoeia of India
- Classical Ayurvedic texts (Charaka Samhita, Sushruta Samhita, Bhavaprakasha Nighantu)

Published by Age Ayurveda in the Nighantu. Educational reference only, not medical advice.
Incorporates material from the Amidha Ayurveda Herb Database under CC BY 4.0.